多聚 ADP 核糖基化——一种细胞应急反应？
Poly ADP-ribosylation--a cellular emergency reaction?
作者信息
Wintersberger U, Wintersberger E
出版信息
FEBS Lett. 1985 Sep 2;188(2):189-91. doi: 10.1016/0014-5793(85)80369-0.
PMID:3928401
Abstract
We propose that the activation of poly(ADP-ribose) synthetase by DNA damage serves to decrease rapidly and transiently the cellular level of NAD (by production therefrom of poly ADP-ribose). The result is a slow-down of energy-requiring reactions, in particular of replicative DNA synthesis giving cells more time to repair the damage. We do not attribute any specific role to poly ADP-ribosylated proteins in this reaction beyond their action as acceptors for poly ADP-ribose.
摘要
我们提出，DNA损伤激活聚（ADP-核糖）合成酶，其作用是迅速且短暂地降低细胞内NAD水平（通过由其产生聚ADP-核糖）。结果是需要能量的反应减缓，特别是复制性DNA合成减缓，从而为细胞提供更多时间来修复损伤。在这个反应中，除了作为聚ADP-核糖的受体之外，我们并未赋予聚ADP-核糖基化蛋白任何特定作用。
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