Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima, Japan.
J Matern Fetal Neonatal Med. 2024 Dec;37(1):2401970. doi: 10.1080/14767058.2024.2401970. Epub 2024 Sep 16.
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder. Late-onset (Lo)-PE can cause serious complications in both the mother and child. This study aimed to explore biomarkers for elucidating the mechanisms underlying Lo-PE, via a metabolomic analysis of first-trimester maternal serum.
This study was conducted at Fukushima Regional Center as an adjunct to Japan Environment and Children Study and included 12 patients with Lo-PE matched to 12 women with healthy pregnancies. Capillary electrophoresis-mass spectrometry-based quantitative analyses of charged metabolites were performed on first-trimester maternal serum samples.
Overall, 183 charged metabolites were identified. The peak area of glucosamine was significantly higher for the first-trimester sera of patients with Lo-PE than that for controls. Conversely, the peak area of serotonin was significantly decreased in the sera of patients with Lo-PE.
During early pregnancy, glucosamine and serotonin levels in maternal serum may serve as early biomarkers for Lo-PE. As part of preconception care, pre-pregnancy dietary habits and mental health could potentially prevent Lo-PE onset.
子痫前期（PE）是一种妊娠特有的高血压疾病。晚发型（Lo）-PE 可导致母婴严重并发症。本研究旨在通过对早孕期母血清进行代谢组学分析，探讨阐明 Lo-PE 发病机制的生物标志物。
本研究在福岛地区中心进行，作为日本环境与儿童研究的补充，共纳入 12 例 Lo-PE 患者和 12 例健康妊娠妇女。对早孕期母血清样本进行基于毛细管电泳-质谱联用的带电荷代谢物定量分析。
共鉴定出 183 种带电荷代谢物。Lo-PE 患者早孕期血清中葡糖胺的峰面积明显高于对照组。相反，Lo-PE 患者血清中 5-羟色胺的峰面积明显降低。
在妊娠早期，母血清中葡糖胺和 5-羟色胺水平可能成为 Lo-PE 的早期生物标志物。作为孕前保健的一部分，孕前饮食习惯和心理健康可能有助于预防 Lo-PE 的发生。
