Zhang Tong, Zou Lin
Clinical Medicine Research Department, Shanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200062, China.
Postgraduate School in Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Cell Death Discov. 2024 Sep 17;10(1):406. doi: 10.1038/s41420-024-02160-7.
Enhancers constitute a vital category of cis-regulatory elements with a Mediator complex within DNA sequences, orchestrating gene expression by activating promoters. In the development of T cells, some enhancers regulate the critical genes, which might also regulate T cell malignant lesions. This review is to comprehensively elucidate the contributions of enhancers in both normal T cell development and its malignant pathogenesis, proposing the idea that the precise subunits of the Mediator complex are the potential drug target for disrupting the specific gene enhancer for T cell malignant diseases.
增强子是DNA序列中一类重要的顺式调控元件，其与中介体复合物共同作用，通过激活启动子来调控基因表达。在T细胞发育过程中，一些增强子调控关键基因，这些基因可能也参与调控T细胞恶性病变。本综述旨在全面阐明增强子在正常T细胞发育及其恶性病变发病机制中的作用，提出中介体复合物的精确亚基是破坏T细胞恶性疾病特异性基因增强子的潜在药物靶点这一观点。
