Henrikson P A, Thilander H, Wåhlander L A
Int J Oral Surg. 1985 Aug;14(4):333-8. doi: 10.1016/s0300-9785(85)80022-3.
In a controlled trial, before having a lower wisdom tooth surgically removed, 190 patients were blindly randomized to 2 parallel groups. One group received 100 mg Voltaren (diclofenac-sodium) before surgery and then 50 mg 3 times a day for 5 days; the other group in Sweden widely used fixed combination tablets (acetylsalicylic acid 500 mg, caffeine 50 mg, aprobarbital 20 mg, codeine phosphate 10 mg) in the highest recommended dose, 2 tablets when needed at most 3 times a day. Twice a day the patients recorded pain and swelling on 100 mm visual analogue scales. Patients treated with Voltaren had significantly less pain and swelling (p less than 0.001). Furthermore, they had significantly fewer days away from work (p less than 0.01). The study indicates that visual analogue scales may also be useful in assessment of swelling and that Voltaren in a fixed dosage offers a promising alternative against postoperative pain and swelling.
在一项对照试验中,190名患者在接受下颌智齿外科拔除术前被随机分为两个平行组。一组在手术前服用100毫克扶他林(双氯芬酸钠),然后每天3次,每次50毫克,共服用5天;另一组在瑞典广泛使用的固定复方片剂(乙酰水杨酸500毫克、咖啡因50毫克、阿普巴比妥20毫克、磷酸可待因10毫克),以最高推荐剂量服用,必要时每天最多3次,每次2片。患者每天两次在100毫米视觉模拟量表上记录疼痛和肿胀情况。服用扶他林治疗的患者疼痛和肿胀明显减轻(p小于0.001)。此外,他们误工天数明显减少(p小于0.01)。该研究表明,视觉模拟量表在评估肿胀方面也可能有用,固定剂量的扶他林在对抗术后疼痛和肿胀方面提供了一种有前景的替代方法。