胰腺脂肪酶浓度升高的猫的心脏生物标志物浓度。
Cardiac biomarker concentrations in cats with elevated pancreatic lipase concentrations.
作者信息
Cridge Harry, DeCicco Barry, Monterroso Stephanie, Steiner Jorg M
机构信息
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Center for Statistical Training and Consulting, Michigan State University, East Lansing, Michigan, USA.
出版信息
Vet Rec. 2025 Feb 1;196(3):e4599. doi: 10.1002/vetr.4599. Epub 2024 Sep 16.
BACKGROUND
Cardiac biomarker concentrations are elevated in dogs with pancreatitis, but it is unknown if this is also the case for cats.
METHODS
The serum feline pancreatic lipase immunoreactivity (fPLI) of serum samples from 60 cats was quantified using the Spec fPL assay. Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I (HST) concentrations were also measured using commercial assays.
RESULTS
Five of 20 cats with fPLI concentrations of 8.8 mg/L or more had above reference interval NT-proBNP concentrations. Serum NT-proBNP concentrations were not correlated with fPLI concentrations (p = 0.31) and were not different in each diagnostic category for fPLI results (p = 0.24). Serum HST concentrations were positively correlated with fPLI concentrations (r = 0.278, 95% confidence interval: 0.02‒0.50, p = 0.03). However, they were not significantly different in each diagnostic category for fPLI results (p = 0.16).
LIMITATIONS
Unidentified co-variates could contribute to the association between fPLI and cardiac biomarker concentrations.
CONCLUSIONS
Cats with elevated fPLI concentrations may have elevated cardiac biomarker concentrations.
背景
胰腺炎犬的心脏生物标志物浓度会升高，但尚不清楚猫是否也是如此。
方法
使用Spec fPL检测法对60只猫的血清样本中的血清猫胰腺脂肪酶免疫反应性（fPLI）进行定量。还使用商业检测法测量血清N末端B型利钠肽原（NT-proBNP）和高敏心肌肌钙蛋白I（HST）的浓度。
结果
20只fPLI浓度为8.8mg/L或更高的猫中，有5只的NT-proBNP浓度高于参考区间。血清NT-proBNP浓度与fPLI浓度无相关性（p = 0.31），且在fPLI结果的每个诊断类别中无差异（p = 0.24）。血清HST浓度与fPLI浓度呈正相关（r = 0.278，95%置信区间：0.02‒0.50，p = 0.03）。然而，在fPLI结果的每个诊断类别中，它们无显著差异（p = 0.16）。
局限性
未识别的协变量可能导致fPLI与心脏生物标志物浓度之间的关联。
结论
fPLI浓度升高的猫可能心脏生物标志物浓度也升高。
Zotero 插件