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孕产妇疟疾感染中的不良妊娠结局：一项系统评价和荟萃分析。

Adverse pregnancy outcomes in maternal malarial infection: A systematic review and meta-analysis.

作者信息

Satapathy Prakasini, Khatib Mahalaqua Nazli, Gaidhane Shilpa, Zahiruddin Quazi Syed, Sharma Rakesh Kumar, Rustagi Sarvesh, Al-Jishi Jumana M, Albayat Hawra, Al Fares Mona A, Garout Mohammed, Alrasheed Hayam A, Al-Subaie Maha F, Rabaan Ali A, Sah Ranjit

机构信息

Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Medical Laboratories Techniques Department, AL-Mustaqbal University, 51001, Hillah, Babil, Iraq.

出版信息

New Microbes New Infect. 2024 Aug 30;62:101474. doi: 10.1016/j.nmni.2024.101474. eCollection 2024 Dec.

DOI:10.1016/j.nmni.2024.101474
PMID:39286328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403273/
Abstract

BACKGROUND

Malaria in pregnancy is a critical public health issue that can lead to severe adverse outcomes for both mother and fetus. This systematic review and meta-analysis evaluated the prevalence of adverse birth outcomes in malaria-infected pregnancies and examines their association with the condition.

METHOD

We searched databases up to January 30, 2024, for observational studies on pregnant women with malaria. Data were analyzed using a random-effects model to calculate pooled prevalence rates and risk ratios (RRs) for adverse outcomes, with statistical support from R software version 4.3.

RESULTS

Thirty-one studies were included, showing high prevalence of low birth weight (LBW; 17.4 %), preterm birth (17.9 %), and small for gestational age (SGA; 16.1 %) in malaria-affected pregnancies. Infected mothers were significantly more likely to have LBW infants (RR = 1.755), preterm births (RR = 1.484), and SGA infants (RR = 1.554). The risk of stillbirth was not significantly increased (RR = 1.238).

CONCLUSION

Malaria in pregnancy significantly elevates the risk of LBW, preterm birth, and SGA, underscoring the need for effective malaria prevention and treatment strategies in endemic regions. Future research should aim to refine and implement these strategies to enhance maternal and neonatal health outcomes.

摘要

背景

妊娠疟疾是一个关键的公共卫生问题，可能导致母亲和胎儿出现严重不良后果。本系统评价和荟萃分析评估了疟疾感染孕妇中不良分娩结局的患病率，并研究了它们与该疾病的关联。

方法

我们检索了截至2024年1月30日的数据库，以查找有关疟疾感染孕妇的观察性研究。使用随机效应模型分析数据，以计算不良结局的合并患病率和风险比（RR），并得到R软件4.3版本的统计支持。

结果

纳入了31项研究，结果显示受疟疾影响的孕妇中低出生体重（LBW；17.4%）、早产（17.9%）和小于胎龄儿（SGA；16.1%）的患病率很高。感染疟疾的母亲生出低出生体重婴儿（RR = 1.755）、早产（RR = 1.484）和小于胎龄儿（RR = 1.554）的可能性显著更高。死产风险没有显著增加（RR = 1.238）。

结论

妊娠疟疾显著增加了低出生体重、早产和小于胎龄儿的风险，这凸显了在流行地区制定有效的疟疾预防和治疗策略的必要性。未来的研究应致力于完善和实施这些策略，以改善孕产妇和新生儿的健康结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/0f54181f3bfc/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/9e0e4444ad43/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/71ae1e135aa4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/5b4c94b931cb/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/452a38560687/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/b86b4505ffff/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/49e8482ce25a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/0f54181f3bfc/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/9e0e4444ad43/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/ac2cd3c9012e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/71ae1e135aa4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/5b4c94b931cb/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/452a38560687/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/b86b4505ffff/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/49e8482ce25a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b70b/11403273/0f54181f3bfc/gr8.jpg

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