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拓展治疗选择:血脂异常新型药物治疗概述。

Expanding therapeutic options: overview of novel pharmacotherapies for dyslipidemia.

机构信息

Department of Internal Medicine, Medical College, Ha'il University, Ha'il, Saudi Arabia.

Department of Cardiology, Libin cardiovascular institute, Calgary University, Calgary, Canada.

出版信息

Expert Opin Pharmacother. 2024 Sep;25(13):1795-1805. doi: 10.1080/14656566.2024.2406270. Epub 2024 Sep 20.

Abstract

INTRODUCTION

Dyslipidemia plays a crucial role in the development of atherosclerotic cardiovascular diseases.

AREAS COVERED

This article explores the emerging therapeutic targets for the treatment of dyslipidemia and provides novel insights into this field. Thus, it aims to contribute to the understanding and advancement of therapeutic options for managing dyslipidemia.

EXPERT OPINION

Optimizing the use of available first- and second-line lipid-lowering drugs allows us to adequately control low-density lipoprotein cholesterol (LDL-C) levels, even in statin-intolerant individuals and in patients at high and very high risk of developing cardiovascular diseases who must reach more aggressive LDL-C targets. The drugs under development will further improve our ability to manage the overall lipid-related cardiovascular disease risk and target other dyslipidemia biomarkers.

摘要

简介

血脂异常在动脉粥样硬化性心血管疾病的发展中起着至关重要的作用。

涵盖领域

本文探讨了血脂异常治疗的新兴治疗靶点,并为该领域提供了新的见解。因此,它旨在有助于理解和推进治疗血脂异常的治疗选择。

专家意见

优化现有一线和二线降脂药物的使用,使我们能够充分控制低密度脂蛋白胆固醇(LDL-C)水平,即使在他汀类药物不耐受的个体以及心血管疾病发生风险高和极高的患者中,这些患者必须达到更积极的 LDL-C 目标。正在开发的药物将进一步提高我们管理整体与脂质相关的心血管疾病风险和靶向其他血脂异常生物标志物的能力。

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