Department of Health Care Services, Nigde Zübeyde Hanım Vocational School of Health Service, Nigde Omer Halisdemir University, Nigde, Turkey.
Department of Midwifery, Zubeyde Hanım Faculty of Health Sciences, Nigde Omer Halisdemir University, Nigde, Turkey.
Acta Cardiol. 2024 Sep;79(7):778-786. doi: 10.1080/00015385.2024.2403933. Epub 2024 Sep 17.
Inflammation plays a crucial role in the progression of acute coronary syndrome.
The aim of this study was to investigate the relationship between the SYNTAX score and new inflammatory markers including albumin-globulin ratio (AGR), C-reactive protein-to-albumin ratio (CAR), fibrinogen-to-albumin ratio (FAR), neutrophil-to-albumin ratio (NAR), and neutrophil percentage-to-albumin ratio (NPAR) in STEMI and NSTEMI patients.
The study involved 53 STEMI and 64 NSTEMI patients, and each patient group was evaluated separately. Multivariate linear regression analysis was utilised to identify independent risk factors associated with SYNTAX scores.
Out of the 64 NSTEMI patients, 42 had low SYNTAX score (65.6%), and 22 had high SYNTAX score (34.4%). Patients with high SYNTAX scores had significantly higher levels of age, glucose, fibrinogen, monocyte, and FAR, and lower levels of albumin and total protein. We found that FAR and monocyte levels were independent predictors of the high SYNTAX score. The study also determined that the cut-off value for FAR as 9.99, with a sensitivity of 81% and a specificity of 73% for predicting high SYNTAX score in NSTEMI patients. Out of the 53 STEMI patients, 42 had low SYNTAX score (79.2%), and 11 had high SYNTAX score (20.8%). Patients with high SYNTAX scores exhibited significantly higher total cholesterol, LDL, and glucose levels, and lower albumin and total protein levels.
The FAR level is significantly linked with the high SYNTAX score and can be a useful marker for predicting the severity of disease in NSTEMI patients.
炎症在急性冠状动脉综合征的进展中起着至关重要的作用。
本研究旨在探讨 SYNTAX 评分与新的炎症标志物（包括白蛋白-球蛋白比值（AGR）、C 反应蛋白与白蛋白比值（CAR）、纤维蛋白原与白蛋白比值（FAR）、中性粒细胞与白蛋白比值（NAR）和中性粒细胞百分比与白蛋白比值（NPAR））之间的关系在 STEMI 和 NSTEMI 患者中的关系。
本研究纳入了 53 例 STEMI 患者和 64 例 NSTEMI 患者，分别对每个患者组进行评估。采用多元线性回归分析来确定与 SYNTAX 评分相关的独立危险因素。
在 64 例 NSTEMI 患者中，42 例患者的 SYNTAX 评分较低（65.6%），22 例患者的 SYNTAX 评分较高（34.4%）。SYNTAX 评分较高的患者年龄、血糖、纤维蛋白原、单核细胞和 FAR 水平显著升高，白蛋白和总蛋白水平显著降低。我们发现 FAR 和单核细胞水平是 SYNTAX 评分较高的独立预测因素。研究还确定，FAR 的截断值为 9.99，对 NSTEMI 患者 SYNTAX 评分较高的预测具有 81%的敏感性和 73%的特异性。在 53 例 STEMI 患者中，42 例患者的 SYNTAX 评分较低（79.2%），11 例患者的 SYNTAX 评分较高（20.8%）。SYNTAX 评分较高的患者总胆固醇、LDL 和血糖水平显著升高，白蛋白和总蛋白水平显著降低。
FAR 水平与 SYNTAX 评分显著相关，可作为预测 NSTEMI 患者疾病严重程度的有用标志物。
