Department of Ophthalmology, Jinan Second People's Hospital, Jinan, China.
Department of Ophthalmology, School of Clinical Medicine, Weifang Medical University, Weifang, China.
Medicine (Baltimore). 2024 Sep 13;103(37):e39588. doi: 10.1097/MD.0000000000039588.
This study aimed to assess the impact of 6 hours of postoperative nasal oxygen therapy on early-stage corneal edema in patients with nuclear cataracts of grades 3 to 4. A retrospective study involved 49 patients (49 eyes) with grades 3 to 4 nuclear cataracts undergoing phacoemulsification and intraocular lens implantation from September 2021 to September 2022. The oxygen group (27 cases) received postoperative nasal oxygen therapy for 6 hours, while the control group (22 cases) received no additional treatment. Corneal edema was evaluated 24 hours postoperatively using a slit lamp microscope, recording the edema degree. The Pentacam anterior segment analyzer measured central corneal thickness (CCT), corneal volume (CV), and corneal optical density (COD) values preoperatively and 24 hours postoperatively. The study enrolled 49 patients. Preoperatively, there were no significant differences between the 2 groups. The oxygen group and the control group exhibited significant differences in CCT, CV, and corneal optical density values before and after surgery for intragroup comparison (all P < .05). At 24 hours postoperatively, the proportion of grade 0 corneal edema in the oxygen therapy group was 59.3%, compared to 31.8% in the control group, with no statistically significant difference (P > .05). The postoperative logMAR visual acuity in the oxygen therapy group was 0.0969 (0.0969, 0.2218), and in the control group it was 0.0969 (0.2218, 0.3979), with a statistically significant difference (P < .05). In oxygen group, the CCT, CV were 585.00 (553.00, 604.00), 68.0 (61.9, 71.3) respectively, all significantly lower than 603.50 (578.50, 788.25), 73.05 (65.3, 75.73) (all P < .05). Statistically significant differences were found in overall COD, COD within specific depth and thickness ranges, and COD within the anterior layer (120 μm thickness) at 24 hours postoperatively (all P < .05). No significant difference was observed in COD values within the central and posterior layers (60 μm thickness) between the 2 groups (all P > .05). Postoperative nasal oxygen therapy for 6 hours immediately after surgery could alleviate the severity of early-stage corneal edema in patients with nuclear cataracts of grades 3 to 4.
本研究旨在评估术后 6 小时鼻部吸氧治疗对 3 至 4 级核性白内障患者早期角膜水肿的影响。这是一项回顾性研究，纳入了 2021 年 9 月至 2022 年 9 月期间接受超声乳化白内障吸除术和人工晶状体植入术的 49 例（49 只眼）3 至 4 级核性白内障患者。吸氧组（27 例）术后接受 6 小时鼻部吸氧治疗，对照组（22 例）不接受额外治疗。术后 24 小时使用裂隙灯显微镜评估角膜水肿程度，记录水肿程度。Pentacam 眼前节分析仪在术前和术后 24 小时测量中央角膜厚度（CCT）、角膜容积（CV）和角膜光学密度（COD）值。该研究共纳入 49 例患者。术前两组间无显著差异。组内比较，吸氧组和对照组术后 CCT、CV 和角膜光学密度值均有显著差异（均 P<0.05）。术后 24 小时，吸氧组角膜水肿 0 级比例为 59.3%，对照组为 31.8%，差异无统计学意义（P>0.05）。吸氧组术后 logMAR 视力为 0.0969（0.0969，0.2218），对照组为 0.0969（0.2218，0.3979），差异有统计学意义（P<0.05）。在吸氧组中，CCT、CV 分别为 585.00（553.00，604.00）、68.0（61.9，71.3），均显著低于 603.50（578.50，688.25）、73.05（65.3，75.73）（均 P<0.05）。术后 24 小时，总体 COD、特定深度和厚度范围内的 COD 以及前层（120μm 厚）的 COD 差异有统计学意义（均 P<0.05）。两组间中央层和后层（60μm 厚）的 COD 值差异无统计学意义（均 P>0.05）。术后立即行 6 小时鼻部吸氧治疗可减轻 3 至 4 级核性白内障患者早期角膜水肿的严重程度。
