1,25-二羟维生素D3和硝苯地平对正常男性催乳素释放的影响。
Effect of 1,25-dihydroxyvitamin D3 and nifedipine on prolactin release in normal man.
作者信息
Verbeelen D, Vanhaelst L, Fuss M, Van Steirteghem A C
出版信息
J Endocrinol Invest. 1985 Apr;8(2):103-6. doi: 10.1007/BF03350657.
PMID:3928730
Abstract
In normal man 1,25 (OH)2-vitamin D3 [1,25 (OH)2D] increases both basal and TRH-stimulated prolactinemia; this effect is completely reversible by the calcium antagonist nifedipine. Similarly the 1,25 (OH)2D-induced hypercalcemia is totally inhibited by nifedipine. These findings suggest that both biological effects of 1,25 (OH)2D are mediated by calcium-dependent mechanisms.
摘要
在正常男性中，1,25（OH）2 - 维生素D3 [1,25（OH）2D]可增加基础催乳素血症和促甲状腺激素释放激素（TRH）刺激的催乳素血症；钙拮抗剂硝苯地平可完全逆转这种作用。同样，硝苯地平可完全抑制1,25（OH）2D诱导的高钙血症。这些发现表明，1,25（OH）2D的两种生物学效应均由钙依赖性机制介导。
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