Department of Urology, Columbia University Irving Medical Center, 161 Fort Washington Avenue 11th Floor, New York, NY, 10032, USA.
Curr Urol Rep. 2024 Sep 17;26(1):1. doi: 10.1007/s11934-024-01238-0.
This manuscript aims to provide a comprehensive overview of the pathophysiology, risk factors, prevention strategies, and management options for radiation cystitis.
Recent studies have shed light on the pathophysiology of radiation cystitis, highlighting the role of inflammation, fibrosis, and vascular damage. Emerging preventive measures like stem cell therapy offer promise, alongside novel treatments such as amniotic bladder therapy and hyperbaric oxygen therapy. This review outlines the latest research on radiation cystitis, covering its pathophysiology, risk factors, prevention, and management. Major findings include insights into the mechanisms of RC development, promising preventive and therapeutic approaches, and the importance of standardized treatment pathways. Future research should focus on identifying genetic risk factors, improving treatment efficacy, and enhancing patient outcomes. This review offers valuable insights for clinicians and researchers, guiding future investigations into radiation cystitis management.
本文旨在全面概述放射性膀胱炎的病理生理学、危险因素、预防策略和治疗选择。
最近的研究揭示了放射性膀胱炎的病理生理学机制,强调了炎症、纤维化和血管损伤的作用。干细胞治疗等新兴预防措施以及羊膜膀胱治疗和高压氧治疗等新疗法都有一定的应用前景。本综述概述了放射性膀胱炎的最新研究,涵盖其病理生理学、危险因素、预防和治疗。主要发现包括对 RC 发展机制的深入了解、有前途的预防和治疗方法,以及标准化治疗途径的重要性。未来的研究应侧重于确定遗传风险因素、提高治疗效果和改善患者预后。本综述为临床医生和研究人员提供了有价值的见解,为未来放射性膀胱炎管理的研究提供了指导。