Gabrichevsky Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
Antiplague Center, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russia.
Bull Exp Biol Med. 2024 Aug;177(4):482-487. doi: 10.1007/s10517-024-06225-6. Epub 2024 Sep 17.
The toxicity and safety of a veterinary anti-salmonella disinfectant based on three highly virulent bacteriophage strains (titers 10 PFU/ml) were studied. Acute, chronic, and inhalation toxicity, as well as local irritancy of the disinfectant were evaluated on outbred white mice CD1 (n=65), Soviet chinchilla rabbits (n=20), and rats (n=20). No toxic effects of the disinfectant was observed after its intraperitoneal or intragastric administration to mice and intragastric administration to rats; in rabbits, application on the skin and eyes produced no local irritation effect. Inhalation of 10% of the disinfectant did not cause any pathologies in mice. Thus, the tests confirmed the high level of safety of the disinfectant based on a mixture of bacteriophages for use as an additional specific disinfection agent against Salmonella in veterinary and livestock facilities.
研究了一种基于三种高毒噬菌体菌株（效价为 10 PFU/ml）的兽医抗沙门氏菌消毒剂的毒性和安全性。对不同品系的小白鼠 CD1（n=65）、苏联兔（n=20）和大鼠（n=20）进行了消毒剂的急性毒性、慢性毒性、吸入毒性和局部刺激性试验。消毒剂经腹腔或胃内给药后对小白鼠无毒性作用，胃内给药对大鼠也无毒性作用；兔皮肤和眼睛应用消毒剂后无局部刺激作用。吸入 10%的消毒剂对小白鼠无任何病理影响。因此，试验证实了基于噬菌体混合物的消毒剂具有很高的安全性，可作为兽医和家畜养殖场中针对沙门氏菌的附加特异性消毒剂。
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