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Is C-reactive protein sufficient to guide antimicrobial therapy for lower respiratory tract infections among children? Results from a stepped-wedge cluster randomized trial in Uganda.C反应蛋白是否足以指导儿童下呼吸道感染的抗菌治疗？乌干达一项阶梯式楔形整群随机试验的结果。
PLoS Med. 2024 Sep 17;21(9):e1004467. doi: 10.1371/journal.pmed.1004467. eCollection 2024 Sep.
2
Point-of-care C-reactive protein measurement by community health workers safely reduces antimicrobial use among children with respiratory illness in rural Uganda: A stepped wedge cluster randomized trial.社区卫生工作者即时检测 C 反应蛋白可安全减少乌干达农村地区呼吸道疾病儿童的抗菌药物使用：一项 stepped wedge 型群组随机试验。
PLoS Med. 2024 Aug 19;21(8):e1004416. doi: 10.1371/journal.pmed.1004416. eCollection 2024 Aug.
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Microbiol Spectr. 2021 Dec 22;9(3):e0169421. doi: 10.1128/Spectrum.01694-21. Epub 2021 Nov 24.
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Point-of-care C-reactive protein testing to reduce inappropriate use of antibiotics for non-severe acute respiratory infections in Vietnamese primary health care: a randomised controlled trial.在越南北部基层医疗中使用即时 C 反应蛋白检测以减少非重症急性呼吸道感染中抗生素的不恰当使用：一项随机对照试验。
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[Therapeutic approach to acute diseases of the respiratory tract in children].
Therapeutique. 1971 Nov;47(9):767-70.
9
Respiratory infections and antimicrobial therapy.呼吸道感染与抗菌治疗。
Arch Otolaryngol. 1969 Jul;90(1):112-4. doi: 10.1001/archotol.1969.00770030114023.
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Effect of C reactive protein point-of-care testing on antibiotic prescribing for lower respiratory tract infections in nursing home residents: cluster randomised controlled trial.C 反应蛋白即时检测对养老院居民下呼吸道感染抗生素处方的影响：整群随机对照试验。
BMJ. 2021 Sep 21;374:n2198. doi: 10.1136/bmj.n2198.

本文引用的文献

1
Point-of-care C-reactive protein measurement by community health workers safely reduces antimicrobial use among children with respiratory illness in rural Uganda: A stepped wedge cluster randomized trial.社区卫生工作者即时检测 C 反应蛋白可安全减少乌干达农村地区呼吸道疾病儿童的抗菌药物使用：一项 stepped wedge 型群组随机试验。
PLoS Med. 2024 Aug 19;21(8):e1004416. doi: 10.1371/journal.pmed.1004416. eCollection 2024 Aug.
2
Prolonged mass azithromycin distributions and macrolide resistance determinants among preschool children in Niger: A sub-study of a cluster-randomized trial (MORDOR).尼日尔学龄前儿童中长时间大规模阿奇霉素分发与大环内酯类耐药决定因素：一项集群随机试验（MORDOR）的子研究。
PLoS Med. 2024 May 6;21(5):e1004386. doi: 10.1371/journal.pmed.1004386. eCollection 2024 May.
3
Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: a systematic analysis from the Global Burden of Disease Study 2021.全球、区域和国家非 COVID-19 下呼吸道感染及病因的发病率、死亡率负担，1990-2021 年：来自 2021 年全球疾病负担研究的系统分析。
Lancet Infect Dis. 2024 Sep;24(9):974-1002. doi: 10.1016/S1473-3099(24)00176-2. Epub 2024 Apr 15.
4
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.对乙酰氨基酚（扑热息痛）或非甾体抗炎药，单独或联合使用，用于缓解儿童急性中耳炎的疼痛。
Cochrane Database Syst Rev. 2023 Aug 18;8(8):CD011534. doi: 10.1002/14651858.CD011534.pub3.
5
Prognostic accuracy of biomarkers of immune and endothelial activation in Mozambican children hospitalized with pneumonia.莫桑比克肺炎住院儿童免疫和内皮激活生物标志物的预后准确性
PLOS Glob Public Health. 2023 Feb 23;3(2):e0001553. doi: 10.1371/journal.pgph.0001553. eCollection 2023.
6
Derivation and validation of a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality in 20 countries.一种新型风险评估工具的推导和验证，用于识别 20 个国家中 2-59 个月龄儿童因肺炎住院相关死亡风险的工具。
BMJ Glob Health. 2022 Apr;7(4). doi: 10.1136/bmjgh-2021-008143.
7
An analysis of clinical predictive values for radiographic pneumonia in children.儿童放射学肺炎的临床预测值分析。
BMJ Glob Health. 2020 Aug;5(8). doi: 10.1136/bmjgh-2020-002708.
8
Amoxicillin for 3 or 5 Days for Chest-Indrawing Pneumonia in Malawian Children.阿莫西林治疗马拉维儿童肺炎性胸腔积液 3 天或 5 天的疗效比较
N Engl J Med. 2020 Jul 2;383(1):13-23. doi: 10.1056/NEJMoa1912400.
9
Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study.无 HIV 感染的非洲和亚洲儿童需住院治疗的严重肺炎的病因：PERCH 多国家病例对照研究。
Lancet. 2019 Aug 31;394(10200):757-779. doi: 10.1016/S0140-6736(19)30721-4. Epub 2019 Jun 27.
10
Placebo vs Amoxicillin for Nonsevere Fast-Breathing Pneumonia in Malawian Children Aged 2 to 59 Months: A Double-blind, Randomized Clinical Noninferiority Trial.安慰剂对比阿莫西林治疗马拉维 2 至 59 月龄儿童非严重呼吸急促性肺炎：一项双盲、随机临床非劣效性试验。
JAMA Pediatr. 2019 Jan 1;173(1):21-28. doi: 10.1001/jamapediatrics.2018.3407.

Is C-reactive protein sufficient to guide antimicrobial therapy for lower respiratory tract infections among children? Results from a stepped-wedge cluster randomized trial in Uganda.

作者信息

Rees Chris A, Mahajan Prashant, Bassat Quique

机构信息

Division of Pediatric Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States of America.

出版信息

PLoS Med. 2024 Sep 17;21(9):e1004467. doi: 10.1371/journal.pmed.1004467. eCollection 2024 Sep.

DOI:10.1371/journal.pmed.1004467
PMID:39288196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11407648/
Abstract
摘要