一项关于卡马西平、苯妥英钠和丙戊酸钠作为单一疗法用于既往未治疗且近期诊断的癫痫患者的前瞻性研究。
A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy.
作者信息
Callaghan N, Kenny R A, O'Neill B, Crowley M, Goggin T
出版信息
J Neurol Neurosurg Psychiatry. 1985 Jul;48(7):639-44. doi: 10.1136/jnnp.48.7.639.
Abstract
One hundred and eighty one patients with previously untreated epilepsy were randomised to sodium valproate, phenytoin or carbamazepine as monotherapy and followed up for a median period which ranged from 14 to 24 months. All three drugs were highly effective in the control of generalised seizures but less effective for partial seizures. Excellent or good control was achieved with therapeutic levels of sodium valproate and carbamazepine, but with subtherapeutic levels of phenytoin.
摘要
181例既往未接受过治疗的癫痫患者被随机分为丙戊酸钠、苯妥英钠或卡马西平单药治疗组，并进行了为期14至24个月的中位随访。所有三种药物在控制全身性癫痫发作方面都非常有效，但对部分性癫痫发作效果较差。丙戊酸钠和卡马西平达到治疗水平时可实现优或良的控制，但苯妥英钠处于亚治疗水平。
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A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy.一项关于卡马西平、苯妥英钠和丙戊酸钠作为单一疗法用于既往未治疗且近期诊断的癫痫患者的前瞻性研究。
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