Concept of flexible no-code automation for complex sample preparation procedures.

Driven by demographic changes and dwindling Science Technology Engineering Mathematics enrolments, our research introduces no-code automation as a strategic response, aimed at mitigating labor shortages while enhancing productivity and safety in the laboratory environment. Employing a user-friendly, no-code software platform, we automated a complex HPTLC assay, enabling laboratory personnel to configure and modify workflows without requiring specialized programming skills. The manuscript outlines the deployment of a collaborative robot (cobot), a programmable logic controller (PLC), and the utilization of self-developed open-source hardware components to establish automated stations for sample handling, incubation, spraying, detection, and storage within the assay process. The research addresses challenges such as the handling of fragile HPTLC plates and the seamless integration of automated stations, solved through innovative design solutions and adaptive programming methods. This investigation demonstrates the feasibility and efficiency of no-code automation in overcoming skilled labor deficits.