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实验室自动化协议 (LAP) 格式和存储库:提高合成生物学工作流程效率的平台。

The Laboratory Automation Protocol (LAP) Format and Repository: A Platform for Enhancing Workflow Efficiency in Synthetic Biology.

机构信息

Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA/CSIC), 28223, Madrid, Spain.

出版信息

ACS Synth Biol. 2023 Dec 15;12(12):3514-3520. doi: 10.1021/acssynbio.3c00397. Epub 2023 Nov 20.

Abstract

Laboratory automation deals with eliminating manual tasks in high-throughput protocols. It therefore plays a crucial role in allowing fast and reliable synthetic biology. However, implementing open-source automation solutions often demands experimental scientists to possess scripting skills, and even when they do, there is no standardized toolkit available for their use. To address this, we present the Laboratory Automation Protocol (LAP) Format and Repository. LAPs adhere to a standardized script-based format, enhancing end-user implementation and simplifying further development. With a modular design, LAPs can be seamlessly combined to create customized, target-specific workflows. Furthermore, all LAPs undergo experimental validation, ensuring their reliability. Detailed information is provided within each repository entry, allowing users to validate the LAPs in their own laboratory settings. We advocate for the adoption of the LAP Format and Repository as a community resource, which will continue to expand, improving the reliability and reproducibility of the automation processes.

摘要

实验室自动化旨在消除高通量方案中的手动任务。因此,它在实现快速可靠的合成生物学方面起着至关重要的作用。然而,实现开源自动化解决方案通常要求实验科学家具备脚本编写技能,即使他们具备这些技能,也没有可用于其使用的标准化工具包。有鉴于此,我们提出了实验室自动化协议(LAP)格式和存储库。LAP 采用标准化的基于脚本的格式,增强了最终用户的实施,并简化了进一步的开发。采用模块化设计,LAP 可以无缝组合以创建定制的、特定于目标的工作流程。此外,所有的 LAP 都经过了实验验证,以确保其可靠性。每个存储库条目的详细信息都提供了,允许用户在自己的实验室环境中验证 LAP。我们提倡采用 LAP 格式和存储库作为社区资源,该资源将不断扩展,提高自动化流程的可靠性和可重复性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6baa/10729298/39d9e6af7b59/sb3c00397_0001.jpg

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