State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 500 Dongchuan Road, Shanghai 200062, China; Region Training and Research Center on Plastic Marine Debris and Microplastics, IOC-UNESCO, 200241, China; Hainan Research Institute of East China Normal University, Sanya 572025, China.
State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 500 Dongchuan Road, Shanghai 200062, China; Region Training and Research Center on Plastic Marine Debris and Microplastics, IOC-UNESCO, 200241, China; Hainan Research Institute of East China Normal University, Sanya 572025, China.
J Hazard Mater. 2024 Dec 5;480:135769. doi: 10.1016/j.jhazmat.2024.135769. Epub 2024 Sep 14.
As newly recognized environmental pollutants, microplastics (MPs, ≤5 mm in length) have been reported in various human tissues and fluids, including the spleen, liver, heart, blood and blood clots, raising global concerns about their impact on human health. This study investigated the characteristics of MPs in intravenous infusion and the removal of MPs from infusion products by infusion sets fitted with different filters using micro-Fourier Transform Infrared Spectroscopy. MPs were detected in infusion products, with an average abundance of 1.24 ± 1.44 items/unit (2.91 ± 3.91 items/L). The primary types of MPs identified were fragmented particles of polyethene and polypropylene, ranging in size from 15-100 µm. Internal filters in infusion sets played a crucial role in removing MPs, particularly fibrous ones, resulting in a reduction in both abundance and particle size of MPs in the human body. Moreover, this study conducted a general assessment of intravenous microplastic exposure among hospital patients and estimated the global per-person input of MPs via intravenous administration. It is an opportunity for us to gain a deeper understanding of MPs in intravenous infusion and provides guides selecting infusion devices, increasing awareness of associated health risks.
作为新认定的环境污染物，微塑料（MPs，长度≤5 毫米）已在各种人体组织和体液中被检出，包括脾、肝、心、血液和血栓，引起了全球对其对人类健康影响的关注。本研究使用配备不同过滤器的输液器，通过微傅里叶变换红外光谱法研究了静脉输液中 MPs 的特征以及输液产品中 MPs 的去除情况。在输液产品中检测到 MPs，平均丰度为 1.24±1.44 项/单位（2.91±3.91 项/L）。鉴定出的 MPs 主要类型为聚乙稀和聚丙烯的碎片颗粒，尺寸在 15-100µm 之间。输液器中的内部过滤器在去除 MPs 方面发挥了关键作用，特别是纤维状过滤器，导致 MPs 的丰度和粒径在人体内均降低。此外，本研究对医院患者的静脉内微塑料暴露进行了总体评估，并通过静脉给药估计了全球每人输入的 MPs 量。这为我们深入了解静脉内输液中的 MPs 提供了机会，并为选择输液装置提供了指导，提高了对相关健康风险的认识。
