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颞叶癫痫与 PLGG。

Temporal PLGG and epilepsy.

机构信息

The Pediatric Neurosurgery Unit, Rambam Health Care Campus, Haifa, Israel.

The Pediatric Brain Center, Gilbert Israeli International Neurofibromatosis Center, Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel.

出版信息

Childs Nerv Syst. 2024 Oct;40(10):3301-3307. doi: 10.1007/s00381-024-06580-9. Epub 2024 Sep 17.

DOI:10.1007/s00381-024-06580-9
PMID:39289197
Abstract

Temporal lobe epilepsy in children is often secondary to various low-grade glial and glioneural tumors and rarely secondary to mesial temporal sclerosis. Despite the benign nature, tumor-associated TLE in children often becomes refractory over time. Abundant literature has shown the significant advantage of tumor resection compared to conservative treatment, in achieving seizure control, as well as the rates of antiseizure medication reduction. Despite these advantages, several considerations are to be related to when considering surgery. These include the impact of surgery on linguistic and neurocognitive development, especially at the younger age; the extent of resection and the role of ECoG; and the need for mesial temporal resection. Over recent years, traditional resection has been complemented with newer treatment options such as laser ablation and biological treatment, and these should be taken into account depending on the exact location and the ability to perform extensive resection in eloquent regions. In this overview manuscript, we discuss the various considerations treating tumor-associated pediatric temporal epilepsy.

摘要

儿童颞叶癫痫常继发于各种低级别神经胶质和神经胶质神经元肿瘤,很少继发于内侧颞叶硬化。尽管肿瘤相关性 TLE 性质良性,但随着时间的推移,儿童肿瘤相关性 TLE 往往变得难治。大量文献表明,与保守治疗相比,肿瘤切除术在控制癫痫发作以及减少抗癫痫药物方面具有显著优势。尽管有这些优势,但在考虑手术时还需要考虑几个因素。这些因素包括手术对语言和神经认知发育的影响,尤其是在年龄较小的情况下;切除的范围和 ECoG 的作用;以及是否需要进行内侧颞叶切除术。近年来,传统的切除术已经得到了新的治疗选择的补充,如激光消融和生物治疗,应根据确切的位置和在功能区进行广泛切除的能力来考虑这些治疗方法。在这篇综述中,我们讨论了治疗与肿瘤相关的儿童颞叶癫痫的各种考虑因素。

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1
Temporal PLGG and epilepsy.颞叶癫痫与 PLGG。
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2
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本文引用的文献

1
Tolerability of transcranial magnetic stimulation language mapping in children.经颅磁刺激语言映射在儿童中的耐受性。
Epilepsy Res. 2023 Aug;194:107183. doi: 10.1016/j.eplepsyres.2023.107183. Epub 2023 Jun 17.
2
Early Epilepsy Surgery in Benign Cerebral Tumors: Avoid Your 'Low-Grade' Becoming a 'Long-Term' Epilepsy-Associated Tumor.良性脑肿瘤的早期癫痫手术:避免你的“低级别”肿瘤变成“长期”癫痫相关肿瘤。
J Clin Med. 2022 Oct 5;11(19):5892. doi: 10.3390/jcm11195892.
3
Brain tumor related epilepsy: pathophysiological approaches and rational management of antiseizure medication.
脑肿瘤相关性癫痫:抗癫痫药物的病理生理学方法及合理管理
Neurol Res Pract. 2022 Sep 5;4(1):45. doi: 10.1186/s42466-022-00205-9.
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The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission.国际抗癫痫联盟局灶性皮质发育不良分类共识:国际抗癫痫联盟诊断方法委员会特别工作组提出的更新建议。
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5
Quantitative Meta-Analyses: Lateralization of Memory Functions Before and After Surgery in Children with Temporal Lobe Epilepsy.定量荟萃分析:颞叶癫痫儿童手术前后记忆功能的偏侧化。
Neuropsychol Rev. 2021 Dec;31(4):535-568. doi: 10.1007/s11065-020-09470-4. Epub 2021 Mar 6.
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Temporal lobe epilepsy surgery in children and adults: A multicenter study.儿童和成人颞叶癫痫手术:一项多中心研究。
Epilepsia. 2021 Jan;62(1):128-142. doi: 10.1111/epi.16772. Epub 2020 Dec 1.
7
Visuospatial learning and memory in children pre- and posttemporal lobe resection: Patterns of localization and lateralization.颞叶切除术前和术后儿童的视空间学习和记忆:定位和偏侧化模式。
Epilepsy Behav. 2019 May;94:189-194. doi: 10.1016/j.yebeh.2019.03.031. Epub 2019 Apr 7.
8
Determinants of IQ outcome after focal epilepsy surgery in childhood: A longitudinal case-control neuroimaging study.儿童局灶性癫痫手术后智商结果的决定因素:一项纵向病例对照神经影像学研究。
Epilepsia. 2019 May;60(5):872-884. doi: 10.1111/epi.14707. Epub 2019 Apr 10.
9
Seizure outcome in pediatric medically refractory temporal lobe epilepsy surgery: selective amygdalohippocampectomy versus anterior temporal lobectomy.小儿药物难治性颞叶癫痫手术的发作结果:选择性杏仁核海马切除术与前颞叶切除术的比较
J Neurosurg Pediatr. 2018 Sep;22(3):276-282. doi: 10.3171/2018.4.PEDS17607. Epub 2018 Jun 22.
10
Seizure and cognitive outcomes after resection of glioneuronal tumors in children.儿童胶质神经元肿瘤切除术后的癫痫发作和认知结果。
Epilepsia. 2018 Jan;59(1):170-178. doi: 10.1111/epi.13961. Epub 2017 Nov 26.