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颞叶癫痫与 PLGG。

Temporal PLGG and epilepsy.

机构信息

The Pediatric Neurosurgery Unit, Rambam Health Care Campus, Haifa, Israel.

The Pediatric Brain Center, Gilbert Israeli International Neurofibromatosis Center, Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv, Israel.

出版信息

Childs Nerv Syst. 2024 Oct;40(10):3301-3307. doi: 10.1007/s00381-024-06580-9. Epub 2024 Sep 17.

Abstract

Temporal lobe epilepsy in children is often secondary to various low-grade glial and glioneural tumors and rarely secondary to mesial temporal sclerosis. Despite the benign nature, tumor-associated TLE in children often becomes refractory over time. Abundant literature has shown the significant advantage of tumor resection compared to conservative treatment, in achieving seizure control, as well as the rates of antiseizure medication reduction. Despite these advantages, several considerations are to be related to when considering surgery. These include the impact of surgery on linguistic and neurocognitive development, especially at the younger age; the extent of resection and the role of ECoG; and the need for mesial temporal resection. Over recent years, traditional resection has been complemented with newer treatment options such as laser ablation and biological treatment, and these should be taken into account depending on the exact location and the ability to perform extensive resection in eloquent regions. In this overview manuscript, we discuss the various considerations treating tumor-associated pediatric temporal epilepsy.

摘要

儿童颞叶癫痫常继发于各种低级别神经胶质和神经胶质神经元肿瘤,很少继发于内侧颞叶硬化。尽管肿瘤相关性 TLE 性质良性,但随着时间的推移,儿童肿瘤相关性 TLE 往往变得难治。大量文献表明,与保守治疗相比,肿瘤切除术在控制癫痫发作以及减少抗癫痫药物方面具有显著优势。尽管有这些优势,但在考虑手术时还需要考虑几个因素。这些因素包括手术对语言和神经认知发育的影响,尤其是在年龄较小的情况下;切除的范围和 ECoG 的作用;以及是否需要进行内侧颞叶切除术。近年来,传统的切除术已经得到了新的治疗选择的补充,如激光消融和生物治疗,应根据确切的位置和在功能区进行广泛切除的能力来考虑这些治疗方法。在这篇综述中,我们讨论了治疗与肿瘤相关的儿童颞叶癫痫的各种考虑因素。

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