Suga S, Kimura K, Iwase H, Ina K, Takada N, Matsuoka S, Matsuura T, Yamada K, Horiuchi T, Hashizume H
Gan No Rinsho. 1985 May;31(6 Suppl):751-6.
It became increasingly evident that UFTM chemotherapy, a combination of UFT and mitomycin C is one of the most recommendable therapy for advanced gastric cancer, especially for the treatment of Borrmann type 4 gastric cancer. Objective responses were achieved in 18 out of 26 (69.2%) patients with Borrmann type 4 gastric cancer. Moreover, UFTM-Dpc treatment, a combination therapy of UFTM plus D-penicillamine (suppressor of collagen synthesis), is proposed for the treatment of Borrmann type 4 gastric cancer from the point of view of collagen synthesis inhibition. It is likely that D-penicillamine might inhibit the peritoneal metastatic involvements, which is lethal to the patients finally.
越来越明显的是，优福定（UFT）与丝裂霉素C联合的UFTM化疗是晚期胃癌最值得推荐的治疗方法之一，尤其是对于Borrmann 4型胃癌的治疗。26例Borrmann 4型胃癌患者中有18例（69.2%）获得了客观缓解。此外，从抑制胶原蛋白合成的角度出发，提出了UFTM-Dpc治疗方案，即UFTM联合D-青霉胺（胶原蛋白合成抑制剂）用于治疗Borrmann 4型胃癌。D-青霉胺可能抑制腹膜转移，而腹膜转移最终对患者是致命的。
