Department of Animal Production, Faculty of Agriculture, Benha University, Benha, Egypt.
Department of Plant Pathology, Faculty of Agriculture, Benha University, Benha, Egypt.
Sci Rep. 2024 Sep 17;14(1):21666. doi: 10.1038/s41598-024-70623-z.
Natural plant extracts offer numerous health benefits for rabbits, including improved feed utilization, antimycotic and antiaflatoxigenic effect, antioxidants, immunological modulation, and growth performance. The aim of the current study was to investigate the effects of silymarin on the performance, hemato-biochemical indices, antioxidants, and villus morphology. A total of 45 Moshtohor 4 weeks old weaned male rabbits were randomly allocated into three groups (15 rabbit/each) each group with 5 replicates. The first group served as the control group feed on an infected diet by aflatoxin B1 (AFB1) 0.02 mg/kg BW, while the second and third groups received an infected diet by AFB1 (0.02 mg/kg BW) and was treated with Silymarin 20 mg/kg BW/day or 30 mg/kg BW/day, respectively. Regarding the growth performance, silymarin supplementation significantly improved the final body weight compared with the control group. Physiologically, silymarin induced high level of dose-dependent total red blood cell count, hematocrit, eosinophils, high-density lipoprotein cholesterol, superoxid dismutase, catalase activity, total antioxidant capacityand intestinal villi width and length. Moreover, silymarin significantly restricted oxidative stress indicators, malondialdehyde, Alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceridein rabbits treated with (AFB1). In conclusion, silymarin supplementation to AFB1 contaminated rabbit diet may mitigate the negative effect of AFB1 on the rabbit performance and health status and increase growth performance, average daily gain, immunological modulation and antioxidants and provide a theoretical basis for the application of silymarin in livestock production.
天然植物提取物为兔子提供了许多健康益处，包括改善饲料利用率、抗真菌和抗黄曲霉毒素作用、抗氧化剂、免疫调节和生长性能。本研究旨在研究水飞蓟素对性能、血液生化指标、抗氧化剂和绒毛形态的影响。总共 45 只 Moshtohor 4 周龄断奶雄性兔子被随机分配到三组（每组 15 只兔子），每组 5 个重复。第一组作为对照组，用黄曲霉毒素 B1（AFB1）0.02mg/kg BW 感染饲料喂养，第二组和第三组用 AFB1（0.02mg/kg BW）感染饲料喂养，分别用 20mg/kg BW/天或 30mg/kg BW/天的水飞蓟素治疗。关于生长性能，水飞蓟素补充剂与对照组相比显著提高了最终体重。从生理上讲，水飞蓟素诱导了高水平的剂量依赖性总红细胞计数、血细胞比容、嗜酸性粒细胞、高密度脂蛋白胆固醇、超氧化物歧化酶、过氧化氢酶活性、总抗氧化能力和肠绒毛宽度和长度。此外，水飞蓟素显著限制了氧化应激指标，丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆固醇、甘油三酯在 AFB1 处理的兔子中。总之，水飞蓟素补充剂添加到 AFB1 污染的兔饲料中可以减轻 AFB1 对兔性能和健康状况的负面影响，提高生长性能、平均日增重、免疫调节和抗氧化剂，并为水飞蓟素在畜牧业生产中的应用提供理论依据。
