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新型冠状病毒病及其他病毒病相关的自身抗体:分子、细胞与临床透视。

Autoantibodies in COVID-19 and Other Viral Diseases: Molecular, Cellular, and Clinical Perspectives.

机构信息

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, South Korea.

Department of Zoology, Fakir Mohan University, Balasore, India.

出版信息

Rev Med Virol. 2024 Sep;34(5):e2583. doi: 10.1002/rmv.2583.

Abstract

Autoantibodies are immune system-produced antibodies that wrongly target the body's cells and tissues for attack. The COVID-19 pandemic has made it possible to link autoantibodies to both the severity of pathogenic infection and the emergence of several autoimmune diseases after recovery from the infection. An overview of autoimmune disorders and the function of autoantibodies in COVID-19 and other infectious diseases are discussed in this review article. We also investigated the different categories of autoantibodies found in COVID-19 and other infectious diseases including the potential pathways by which they contribute to the severity of the illness. Additionally, it also highlights the probable connection between vaccine-induced autoantibodies and their adverse outcomes. The review also discusses the therapeutic perspectives of autoantibodies. This paper advances our knowledge about the intricate interaction between autoantibodies and COVID-19 by thoroughly assessing the most recent findings.

摘要

自身抗体是免疫系统产生的抗体,它们错误地将身体的细胞和组织作为攻击目标。COVID-19 大流行使得将自身抗体与致病性感染的严重程度以及感染后出现的几种自身免疫性疾病联系起来成为可能。本文综述了自身免疫性疾病以及自身抗体在 COVID-19 和其他传染病中的作用。我们还研究了 COVID-19 和其他传染病中发现的不同类别的自身抗体,包括它们导致疾病严重程度的潜在途径。此外,它还强调了疫苗诱导的自身抗体及其不良后果之间可能存在的联系。该综述还讨论了自身抗体的治疗前景。本文通过深入评估最新发现,增进了我们对自身抗体与 COVID-19 之间复杂相互作用的了解。

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