Zhang Huhu, Sun Fulin, Jiang Shuyao, Yang Fanghao, Dong Xiaolei, Liu Guoxiang, Wang Mengjun, Li Ya, Su Mohan, Wen Ziyuan, Yu Chunjuan, Fan Chenkai, Li Xiaoxia, Zhang Zhe, Yang Lina, Li Bing
Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao, 266071, China.
Health Science Center, Qingdao University, Qingdao, 266071, China.
Biomark Res. 2024 Sep 17;12(1):105. doi: 10.1186/s40364-024-00652-3.
Methyltransferase-like protein is a ubiquitous enzyme-like protein in the human body, with binding domains for nucleic acids, proteins and other small molecules, and plays an important role in a variety of biological behaviours in normal organisms and diseases, characterised by the presence of a methyltransferase-like structural domain and a structurally conserved SAM-binding domain formed by the seven-stranded β-fold structure in the center of the protein. With the deepening of research, the METTL protein family has been found to be abnormally expressed in a variety of tumor diseases, and the clarification of its relationship with tumor diseases can be used as a molecular therapeutic target and has an important role in the prognosis of tumors. In this paper, we review the structure, biological process, immunotherapy, drug-targeted therapy, and markers of the METTL protein family to provide new ideas for the diagnosis and treatment of tumors.
甲基转移酶样蛋白是人体中一种普遍存在的类酶蛋白，具有核酸、蛋白质和其他小分子的结合结构域，在正常生物体和疾病的多种生物学行为中发挥重要作用，其特征是存在一个甲基转移酶样结构域和一个由蛋白质中心的七链β折叠结构形成的结构保守的SAM结合结构域。随着研究的深入，发现METTL蛋白家族在多种肿瘤疾病中异常表达，阐明其与肿瘤疾病的关系可作为分子治疗靶点，对肿瘤预后具有重要作用。本文综述了METTL蛋白家族的结构、生物学过程、免疫治疗、药物靶向治疗及标志物，为肿瘤的诊断和治疗提供新思路。
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