Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan, China.
Shanxi Research Institute of 6D Artificial Intelligence Biomedical Science, Taiyuan, China.
Biotechnol Bioeng. 2024 Dec;121(12):3768-3781. doi: 10.1002/bit.28850. Epub 2024 Sep 17.
3D bioprinting technology is widely used in biomedical fields such as tissue regeneration and constructing pathological model. The prevailing printing technique is extrusion-based bioprinting. In this printing method, the bioink needs to meet both printability and functionality, which are often conflicting requirements. Therefore, this study has developed an innovative microvalve-based equipment, incorporating components such as pressure control, a three-dimensional motion platform, and microvalve. Here, we present a droplet-based method for constructing complex three-dimensional structures. By leveraging the rapid switching characteristics of the microvalve, this equipment can achieve precise printing of bio-materials with viscosities as low as 10mPa·s, significantly expanding the biofabrication window for bioinks. This technology is of great significance for 3D bioprinting in tissue engineering and lays a solid foundation for the construction of complex artificial organ tissues.
3D 生物打印技术广泛应用于组织再生和构建病理模型等生物医学领域。目前流行的打印技术是基于挤出的生物打印。在这种打印方法中，生物墨水需要同时满足可打印性和功能性，这通常是相互矛盾的要求。因此，本研究开发了一种基于微阀的创新设备，该设备集成了压力控制、三维运动平台和微阀等组件。在这里，我们提出了一种基于液滴的构建复杂三维结构的方法。利用微阀的快速切换特性，该设备可以精确地打印低至 10mPa·s 粘度的生物材料，极大地扩展了生物墨水的生物制造窗口。这项技术对于组织工程中的 3D 生物打印具有重要意义，为复杂人工器官组织的构建奠定了坚实的基础。
