The Department of General Surgery, Ganzhou People's Hospital, Ganzhou, Jiangxi, People's Republic of China.
Sci Prog. 2024 Jul-Sep;107(3):368504241283352. doi: 10.1177/00368504241283352.
The primary treatment for varicose ulcers is to address the underlying cause of venous hypertension, additionally, split-thickness skin transplantation (ST) is an effective option for large ulcers. The aim of this study was to compare the efficacy of venous surgery with or without split-thickness ST in the management of varicose ulcers (diameter ≥6 cm).
Patients with varicose ulcers between 2013 and 2023 were included in the real-world retrospective cohort study. The endovenous microwave ablation/endovenous laser ablation-high ligation-foam sclerotherapy-compression therapy + ST group (EMA/EVLA-CT-HL-FS + ST) consisted of 32 patients, while the EMA/EVLA-CT-HL-FS group consisted of 48 patients.
A difference in ulcer healing time was found between the two groups (the hazard ratio [HR] was 4.4, 95% CI [2.3-8.2], P < 0.0001). However, the healing rate did not differ between the two groups at 6 and 12 months postoperatively.
ST has been shown to expedite ulcer healing and ameliorate the symptoms of VVs in the early stages of treatment, while its intermediate to long-term efficacy for ulcer healing and overall patient quality of life may be limited.
静脉曲张性溃疡的主要治疗方法是解决静脉高压的根本原因，此外，中厚皮片移植（ST）是治疗大溃疡的有效选择。本研究旨在比较静脉手术联合或不联合 ST 治疗直径≥6cm 静脉曲张性溃疡的疗效。
本真实世界回顾性队列研究纳入了 2013 年至 2023 年间的静脉曲张性溃疡患者。腔内微波消融/腔内激光消融-高位结扎-泡沫硬化剂治疗-压迫治疗+ST 组（EMA/EVLA-CT-HL-FS+ST）包括 32 例患者，而 EMA/EVLA-CT-HL-FS 组包括 48 例患者。
两组溃疡愈合时间存在差异（风险比 [HR]为 4.4，95%可信区间 [2.3-8.2]，P<0.0001）。然而，两组患者术后 6 个月和 12 个月的愈合率无差异。
ST 已被证明可加速溃疡愈合，并在治疗早期改善 VVs 的症状，但它对溃疡愈合和整体患者生活质量的中期至长期疗效可能有限。
