Shaw R W, Kerr-Wilson R H, Fraser H M, McNeilly A S, Howie P W, Sandow J
Maturitas. 1985 Jul;7(2):161-7. doi: 10.1016/0378-5122(85)90022-2.
Alterations in circulating gonadotrophins have been reported at the time of onset of menopausal flushes. In order to study this association D-SER(TBU)6-EA10-LHRH, a luteinizing hormone releasing hormone (LHRH) agonist was given intranasally at a dose of 200 micrograms twice daily to 12 post-menopausal women to study its effect on gonadotrophin secretion and hot flushes. Following an initial period of 3-5 days of increased gonadotrophin secretion, pituitary desensitization occurred, with a significant suppression of circulating LH and follicle-stimulating hormone (FSH) levels (P less than 0.001) and a reduction in gonadotrophin pulse amplitude (P less than 0.05). This was accompanied by a significant diminution of the pituitary's response to exogenous LHRH (P less than 0.05). However, no significant alteration in the incidence of hot flushes was observed on such therapy.
据报道，在绝经潮红发作时循环促性腺激素会发生变化。为了研究这种关联，对12名绝经后妇女每天两次经鼻给予剂量为200微克的D - SER(TBU)6 - EA10 - LHRH（一种促黄体生成素释放激素（LHRH）激动剂），以研究其对促性腺激素分泌和潮热的影响。在促性腺激素分泌增加的初始3 - 5天之后，垂体脱敏发生，循环中的促黄体生成素（LH）和促卵泡激素（FSH）水平显著受到抑制（P小于0.001），促性腺激素脉冲幅度降低（P小于0.05）。这伴随着垂体对外源性LHRH反应的显著减弱（P小于0.05）。然而，这种治疗并未观察到潮热发生率有显著变化。
