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N1-methylpseudouridine modification level correlates with protein expression, immunogenicity, and stability of mRNA.

作者信息

Chen Shaoyi, Liu Zheng, Cai Jingsheng, Li Haoran, Qiu Mantang

机构信息

Department of Thoracic Surgery Thoracic Oncology Institute and Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer Peking University People's Hospital Beijing China.

Institute of Advanced Clinical Medicine Peking University Beijing China.

出版信息

MedComm (2020). 2024 Sep 17;5(10):e691. doi: 10.1002/mco2.691. eCollection 2024 Oct.

DOI:10.1002/mco2.691
PMID:39290255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11406044/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a287/11406044/a6086374e3ed/MCO2-5-e691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a287/11406044/a6086374e3ed/MCO2-5-e691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a287/11406044/a6086374e3ed/MCO2-5-e691-g001.jpg

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N1-methylpseudouridine modification level correlates with protein expression, immunogenicity, and stability of mRNA.N1-甲基假尿苷修饰水平与mRNA的蛋白质表达、免疫原性和稳定性相关。
MedComm (2020). 2024 Sep 17;5(10):e691. doi: 10.1002/mco2.691. eCollection 2024 Oct.
2
Pseudouridine and 1-methylpseudouridine as potent nucleotide analogues for RNA therapy and vaccine development.假尿苷和1-甲基假尿苷作为RNA治疗和疫苗开发的有效核苷酸类似物。
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The mRNACalc webserver accounts for the N1-methylpseudouridine hypochromicity to enable precise nucleoside-modified mRNA quantification.mRNACalc网络服务器考虑到N1-甲基假尿苷的减色效应，以实现对核苷修饰的mRNA进行精确量化。
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Influence of N1-Methylpseudouridine in Guide RNAs on CRISPR/Cas9 Activity.向导 RNA 中 N1-甲基假尿嘧啶核苷对 CRISPR/Cas9 活性的影响。
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N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.N(1)-甲基假尿嘧啶核苷修饰的 mRNA 在哺乳动物细胞系和小鼠中表现优于假尿嘧啶核苷修饰的 mRNA，可提供更高的蛋白表达和降低免疫原性。
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本文引用的文献

1
Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs.基于膜的翻译延伸阻滞解除在假尿嘧啶核苷和 N1-甲基假尿嘧啶核苷修饰的 mRNAs 上。
Nucleic Acids Res. 2022 Jul 22;50(13):7202-7215. doi: 10.1093/nar/gkab1241.
2
mRNA structure regulates protein expression through changes in functional half-life.mRNA 结构通过改变功能半衰期来调节蛋白质表达。
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. doi: 10.1073/pnas.1908052116. Epub 2019 Nov 11.
3
Sensing Self and Foreign Circular RNAs by Intron Identity.
通过内含子特性感知自身与外源环状RNA
Mol Cell. 2017 Jul 20;67(2):228-238.e5. doi: 10.1016/j.molcel.2017.05.022. Epub 2017 Jun 15.
4
N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.N(1)-甲基假尿嘧啶核苷修饰的 mRNA 在哺乳动物细胞系和小鼠中表现优于假尿嘧啶核苷修饰的 mRNA，可提供更高的蛋白表达和降低免疫原性。
J Control Release. 2015 Nov 10;217:337-44. doi: 10.1016/j.jconrel.2015.08.051. Epub 2015 Sep 3.
5
Toll-like receptor 8 senses degradation products of single-stranded RNA.Toll 样受体 8 感知单链 RNA 的降解产物。
Nat Struct Mol Biol. 2015 Feb;22(2):109-15. doi: 10.1038/nsmb.2943. Epub 2015 Jan 19.