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伊拉克急性髓系白血病患者中PD-1的基因多态性与免疫评估

Genetic polymorphism and immunological evaluation of PD-1 in Iraqi patients with acute myeloid leukemia.

作者信息

Mahmood Aseel S

机构信息

Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq.

出版信息

J Adv Pharm Technol Res. 2024 Jul-Sep;15(3):225-230. doi: 10.4103/JAPTR.JAPTR_107_24. Epub 2024 Jul 22.

DOI:10.4103/JAPTR.JAPTR_107_24
PMID:39290538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404430/
Abstract

PD-1 has a noteworthy function in developing acute myeloid leukemia (AML). The expression of PD-1 on effector T cells is regulated at the protein level depending on the interactions between cells. The objective of the study was to evaluate the PD-1 concentration levels and the polymorphism genetic variants (rs36084323 G/A) in Iraqi Arab patients with AML. Sanger's DNA sequencing was used, and the assessments were done by enzyme-linked immunosorbent assay and PD-1 gene polymorphism SNP rs36084323 G/A. The frequency of rs36084323 was significantly different between AML and control, with a lower risk for AML seen in patients with GA genotype (odds ratio; 95% confidence interval: 0.53; 0.32-0.87). PD-1 elevated AML compared to control (213.1 pg/mL vs. 178.8 pg/mL). in AML patients, there is upregulation in PD-1, which indicates that PD-1 is a possible biomarker for AML. PD-1 rs36084323 G/A may have a role in AML risk.

摘要

程序性死亡受体1（PD-1）在急性髓系白血病（AML）的发生发展中具有重要作用。效应T细胞上PD-1的表达在蛋白质水平上受细胞间相互作用的调控。本研究的目的是评估伊拉克阿拉伯AML患者的PD-1浓度水平及多态性基因变异（rs36084323 G/A）。采用桑格DNA测序法，并通过酶联免疫吸附测定法和PD-1基因多态性SNP rs36084323 G/A进行评估。rs36084323的频率在AML患者和对照组之间存在显著差异，GA基因型患者患AML的风险较低（比值比；95%置信区间：0.53；0.32 - 0.87）。与对照组相比，AML患者的PD-1水平升高（213.1 pg/mL对178.8 pg/mL）。在AML患者中，PD-1表达上调，这表明PD-1可能是AML的一个生物标志物。PD-1 rs36084323 G/A可能在AML风险中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/47f3d41e9bf6/JAPTR-15-225-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/ce16a6589444/JAPTR-15-225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/d50fde4b07c7/JAPTR-15-225-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/634e879f0ba1/JAPTR-15-225-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/47f3d41e9bf6/JAPTR-15-225-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/ce16a6589444/JAPTR-15-225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/d50fde4b07c7/JAPTR-15-225-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/634e879f0ba1/JAPTR-15-225-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1451/11404430/47f3d41e9bf6/JAPTR-15-225-g004.jpg

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