Sithisarn Patchima, Rojsanga Piyanuch, Ruenraroengsak Pakatip, Sithisarn Pongtip
Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Kampangsaen Campus, Nakhon Pathom, Bangkok, Thailand.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
J Adv Pharm Technol Res. 2024 Jul-Sep;15(3):156-160. doi: 10.4103/JAPTR.JAPTR_97_24. Epub 2024 Jul 22.
A topical antimicrobial ointment was developed from the fruit extract of and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of and evaluate for its antibacterial and wound-healing effects. fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. ointment promoted antibacterial activity and wound-healing effect in dogs with no acute toxicity.
一种由[植物名称]果实提取物制成的外用抗菌软膏，并在动物模型中对其抗菌、伤口愈合效果及急性毒性进行了评估。[植物名称]的果实和种子提取物对临床分离细菌表现出抗菌活性，并具有抗氧化活性。为了从[植物名称]果实提取物开发一种外用抗菌软膏并评估其抗菌和伤口愈合效果。制备了[植物名称]果实提取物软膏并进行了质量控制。在动物模型中评估了提取物的急性毒性。研究了该软膏对犬伤口的抗菌效果和愈合效果。结果以平均值±标准差表示。该软膏表现出[具体抗菌效果]。每天一次将该软膏应用于犬伤口具有伤口愈合效果，7天内完全上皮化，同时伤口在12天内随着痂皮脱落而完全愈合，面积减小至原始大小的14%。在动物模型中未发现该软膏有急性毒性。[植物名称]软膏在犬中促进了抗菌活性和伤口愈合效果且无急性毒性。
