Shao Xiufang, Ren Kunhai, Tang Haiyan, Xiu Yingling, Pan Mian
Gynaecology and Obstetrics, Fujian Maternity and Child Health Hospital, Fuzhou 350000, China.
Clinical Lab, Fujian Maternity and Child Health Hospital, Fuzhou 350000, China.
J Healthc Eng. 2022 Apr 15;2022:2063049. doi: 10.1155/2022/2063049. eCollection 2022.
The purpose of this paper is to explore the relationship between serum thyroid-stimulating hormone (TSH) levels and adverse pregnancy outcomes in advanced maternal age. A total of 97 elderly parturient women who were treated in our hospital from June 2020 to March 2021 are included in this study. According to the TSH level, the parturient women are divided into three groups, including A (<0.25 IU/ml), B (>4.00 IU/ml), and C (0.25-4.00 IU/ml) groups. The clinical data of all parturients are collected and sorted out. The serum levels of TSH, free triiodothyronine (FT3), and free thyroxine (FT4) are measured by chemiluminescence immunoassay. The levels of immunoglobulin (Ig) A, IgG, and IgM are determined by immunoturbidimetry. The incidence of adverse pregnancy outcomes is analyzed. The birth weight and Apgar score of newborns in the three groups are compared. The TSH level in group A is significantly lower than that in groups B and C, but the levels of FT3 and FT4 in group A are notably higher than those in groups B and C ( < 0.05). The levels of IgA, IgG, and IgM in group A are significantly higher than those in groups B and C ( < 0.05). The incidence of adverse pregnancy outcomes in group C is 2.38%, which is obviously lower than the 20.00% in group A and 17.14% in group B ( < 0.05). The birth weight and Apgar score of infants in group A and group B are significantly lower than those in group C ( < 0.05). TSH has a great influence on the pregnancy outcome in advanced maternal age, which should be paid more attention in clinic.
本文旨在探讨高龄产妇血清促甲状腺激素（TSH）水平与不良妊娠结局之间的关系。本研究纳入了2020年6月至2021年3月在我院接受治疗的97例高龄产妇。根据TSH水平，将产妇分为三组，包括A组（<0.25 IU/ml）、B组（>4.00 IU/ml）和C组（0.25 - 4.00 IU/ml）。收集并整理所有产妇的临床资料。采用化学发光免疫分析法测定血清TSH、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平。采用免疫比浊法测定免疫球蛋白（Ig）A、IgG和IgM水平。分析不良妊娠结局的发生率。比较三组新生儿的出生体重和阿氏评分。A组TSH水平显著低于B组和C组，但A组FT3和FT4水平显著高于B组和C组（<0.05）。A组IgA、IgG和IgM水平显著高于B组和C组（<0.05）。C组不良妊娠结局发生率为2.38%，明显低于A组的20.00%和B组的17.14%（<0.05）。A组和B组婴儿的出生体重和阿氏评分显著低于C组（<0.05）。TSH对高龄产妇的妊娠结局有很大影响，临床应予以更多关注。
