Alderson T
Mutat Res. 1985 Sep;154(2):101-10. doi: 10.1016/0165-1110(85)90022-3.
A novel and unique mechanism for formaldehyde-induced mutagenesis is described which is mediated by the formation of an N6-substituted adenine ribonucleoside analogue, N6-hydroxymethyl adenosine, after an in vitro reaction of formaldehyde with adenosine. This type of ribonucleoside analogue (the deoxyribose derivative is ineffective) exhibits a powerful and remarkable germ-cell-stage-specific mutagenic effect in male Drosophila larvae, apparently by interfering with DNA repair. Circumstantial evidence is presented which indicates that the analogue most probably acts by its utilisation in the synthesis of diadenosine tetraphosphate (Ap4A) to form an antimetabolite(s) of Ap4A which subsequently interferes with Ap4A-mediated intracellular events, amongst which an effect on DNA repair would appear to be its mutagenic mechanism of action.
描述了一种由甲醛诱导诱变的新颖独特机制，该机制由甲醛与腺苷在体外反应后形成N6-取代腺嘌呤核糖核苷类似物N6-羟甲基腺苷介导。这种核糖核苷类似物（脱氧核糖衍生物无效）在雄性果蝇幼虫的生殖细胞阶段表现出强大且显著的诱变作用，显然是通过干扰DNA修复实现的。文中提供了间接证据，表明该类似物很可能通过在四磷酸二腺苷（Ap4A）合成中被利用，形成Ap4A的抗代谢物，进而干扰Ap4A介导的细胞内事件，其中对DNA修复的影响似乎是其诱变作用机制。
