Gharib Amal F, Elsawy Wael H, Alrehaili Amani A, Amin Hanan S, Alhuthali Hayaa M, Bakhuraysah Maha M, El Askary Ahmad
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O.Box 11099, Taif 21944, Saudi Arabia.
Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Egypt.
Comput Math Methods Med. 2022 Feb 23;2022:1514412. doi: 10.1155/2022/1514412. eCollection 2022.
To study the problem in esophageal cancer, the function of SOX2 and miR-126 has not been completely explored. The objective of this study was to find out how SOX2 and miR-126 act in esophageal cancer and their relation to the clinical and prognostic features.
The expression of SOX2 and miR-126 was properly assessed in the carcinoma of the esophagus, and the nearby healthy tissues surgically excised from 35 included patients.
SOX2 was elevated in esophageal cancer relative to normal tissues contrary to the miR-126 levels. This inverse relationship was linked to adverse clinical features.
SOX2 has been involved as an oncogene in various types of malignant tumors; microRNA-126 (miR-126) is extensively expressed in vascular endothelial cells, which control angiogenesis. Furthermore, many published reports reasonably concluded that based on the prime characteristic of malignant cells, miR-126 may act appropriately as a promotor or a suppressor for the malignant growth.
In esophageal cancer, SOX2 works as an oncogene, whereas miR-126 acts as a tumor suppressor gene. SOX2 overexpression and miR-126 downregulation were shown to be linked to a poor prognosis.
为研究食管癌中尚未完全明确的SOX2和miR - 126的功能问题。本研究旨在探究SOX2和miR - 126在食管癌中的作用机制及其与临床和预后特征的关系。
对35例纳入研究的患者手术切除的食管癌组织及癌旁正常组织中SOX2和miR - 126的表达进行了恰当评估。
与正常组织相比，食管癌中SOX2表达升高，而miR - 126水平相反。这种负相关关系与不良临床特征相关。
SOX2在多种恶性肿瘤中作为癌基因发挥作用；微小RNA - 126（miR - 126）在血管内皮细胞中广泛表达，调控血管生成。此外，许多已发表的报告合理推断，基于癌细胞的主要特性，miR - 126可能作为恶性生长的促进因子或抑制因子发挥作用。
在食管癌中，SOX2作为癌基因发挥作用，而miR - 126作为抑癌基因发挥作用。SOX2过表达和miR - 126下调与预后不良相关。
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