环状GMP-AMP合酶（cGAS）抑制剂作为自身免疫性和炎性疾病的潜在治疗方法
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases.
作者信息
Abdel-Magid Ahmed F
机构信息
PI Health Sciences, 100 Jade Park, Chelsea, Alabama 35043, United States.
出版信息
ACS Med Chem Lett. 2024 Aug 22;15(9):1424-1426. doi: 10.1021/acsmedchemlett.4c00392. eCollection 2024 Sep 12.
Abstract
The invention in this patent application relates to macrocyclic benzimidazole derivatives represented herein generally by Formula 1. The compounds of Formula 1 are cGAS inhibitors and may potentially provide treatments of autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, and others.
摘要
本专利申请中的发明涉及一般由式1表示的大环苯并咪唑衍生物。式1的化合物是环鸟苷酸合成酶（cGAS）抑制剂，可能为自身免疫性疾病如系统性红斑狼疮、系统性硬化症（SSc）、干扰素病等提供治疗方法。
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