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一名接受粒细胞集落刺激因子治疗的患者出现大血管血管炎：不明原因发热的一种可能鉴别诊断。

Large Vessel Vasculitis in a Patient Receiving G-CSF: A Possible Differential for Fever of Unknown Origin.

作者信息

Mahdi Raza Abbas, Krishnaraju Venkata Subramanian, Mittal Bhagwant Rai, Singh Harmandeep, Kumar Rajender, Prakash Gaurav

机构信息

Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Indian J Nucl Med. 2024 May-Jun;39(3):224-226. doi: 10.4103/ijnm.ijnm_138_23. Epub 2024 Aug 17.

DOI:10.4103/ijnm.ijnm_138_23
PMID:39291059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404730/
Abstract

Large vessel vasculitis is a known but rare side effect of granulocyte colony-stimulating factor (G-CSF) therapy. We report a case of adenocarcinoma lung with pleural infiltration and mediastinal lymphadenopathy, who was treated with neoadjuvant chemotherapy and pegylated G-CSF. After three cycles, he developed a fever. He underwent F-18 fludeoxyglucose (FDG) positron emission tomography computed tomography for fever of unkwnown origin evaluation, which revealed a response to chemotherapy along with the appearance of FDG avid mural thickening in a few large arteries, suggesting a diagnosis of G-CSF-induced large vessel vasculitis.

摘要

大血管血管炎是粒细胞集落刺激因子（G-CSF）治疗已知但罕见的副作用。我们报告一例伴有胸膜浸润和纵隔淋巴结肿大的肺腺癌患者，该患者接受了新辅助化疗和聚乙二醇化G-CSF治疗。三个周期后，他出现发热。他接受了F-18氟脱氧葡萄糖（FDG）正电子发射断层扫描计算机断层扫描以评估不明原因发热，结果显示对化疗有反应，同时在一些大动脉中出现FDG摄取增加的血管壁增厚，提示诊断为G-CSF诱导的大血管血管炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7b7/11404730/3ef1f4e2607e/IJNM-39-224-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7b7/11404730/3ef1f4e2607e/IJNM-39-224-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7b7/11404730/3ef1f4e2607e/IJNM-39-224-g001.jpg

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本文引用的文献

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Curr Rheumatol Rep. 2022 Nov;24(11):323-336. doi: 10.1007/s11926-022-01088-0. Epub 2022 Sep 21.
2
G-CSF-induced carotid inflammation.粒细胞集落刺激因子诱导的颈动脉炎症。
Lancet Oncol. 2022 May;23(5):e235. doi: 10.1016/S1470-2045(22)00074-2.
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G-CSF and G-CSF-related vasculitis: a systematic review of the literature and intriguing future research perspectives.粒细胞集落刺激因子（G-CSF）和 G-CSF 相关血管炎：文献系统回顾及有趣的未来研究展望。
Future Oncol. 2021 Nov;17(33):4619-4634. doi: 10.2217/fon-2021-0701. Epub 2021 Aug 25.
4
Large vessel vasculitis secondary to granulocyte-colony stimulating factor.继发于粒细胞集落刺激因子的大血管血管炎。
Vasa. 2020 Oct;49(6):509-513. doi: 10.1024/0301-1526/a000872. Epub 2020 May 26.
5
Pegfilgrastim-associated large-vessel vasculitis developed during adjuvant chemotherapy for breast cancer: A case report and review of the literature.培非格司亭相关的大血管血管炎在乳腺癌辅助化疗期间发生：一例病例报告及文献复习
J Oncol Pharm Pract. 2020 Oct;26(7):1785-1790. doi: 10.1177/1078155220910800. Epub 2020 Mar 18.
6
Granulocyte colony-stimulating factor- and chemotherapy-induced large-vessel vasculitis: six patient cases and a systematic literature review.粒细胞集落刺激因子与化疗诱导的大血管血管炎：6例患者病例及系统文献综述
Rheumatol Adv Pract. 2020 Feb 6;4(1):rkaa004. doi: 10.1093/rap/rkaa004. eCollection 2020.
7
Granulocyte-colony stimulating factor-associated aortitis in a woman with advanced breast cancer: a case report and review of the literature.粒细胞集落刺激因子相关性主动脉炎在一名晚期乳腺癌女性中的表现：病例报告及文献复习。
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Arteritis after administration of granulocyte colony-stimulating factor: a case series.粒细胞集落刺激因子治疗后的动脉炎：病例系列。
Int J Hematol. 2019 Sep;110(3):370-374. doi: 10.1007/s12185-019-02662-6. Epub 2019 May 14.
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Autoimmun Rev. 2019 Jun;18(6):615-620. doi: 10.1016/j.autrev.2018.12.011. Epub 2019 Apr 5.
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Rinsho Ketsueki. 2017;58(11):2238-2242. doi: 10.11406/rinketsu.58.2238.