Consultant, Department of Medicine, Sir Ganga Ram Hospital, New Delhi, India, Corresponding Author.
Senior Consultant, Department of Medicine, Sir Ganga Ram Hospital, New Delhi, India.
J Assoc Physicians India. 2024 Sep;72(9):e29-e30. doi: 10.59556/japi.72.0623.
A lot of autoimmune conditions have been found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are multiple cases of autoimmune and autoinflammatory diseases reported after the coronavirus disease 2019 (COVID-19) pandemic. Autoimmune neurological presentations have also been reported but are very rare. Morvan's syndrome is a life-threatening autoimmune disease and is very rare. Morvan's syndrome is classically characterized by neuromyotonia, dysautonomia, insomnia, and neuropsychiatric symptoms. Leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein 2 (CASPR2) autoimmunity has also been associated with Morvan's syndrome. We hereby report an interesting case of a male patient in his 40s, who had a history of COVID-19 infection, following which he had bilateral lower-limb weakness and pain, with profuse sweating, and was later diagnosed as a case of SARS-CoV-2-associated Morvan's syndrome.
许多自身免疫性疾病已被发现与严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）有关。在 2019 年冠状病毒病（COVID-19）大流行之后，有多种自身免疫和自身炎症性疾病的报告。也有报道称出现了自身免疫性神经表现，但非常罕见。莫旺综合征是一种危及生命的自身免疫性疾病，非常罕见。莫旺综合征的特征通常是肌强直、自主神经功能紊乱、失眠和神经精神症状。亮氨酸丰富的胶质瘤失活蛋白 1（LGI1）和接触蛋白相关蛋白 2（CASPR2）自身免疫也与莫旺综合征有关。我们在此报告一例 40 多岁男性患者的有趣病例，该患者有 COVID-19 感染史，随后出现双侧下肢无力和疼痛，大量出汗，后来被诊断为 SARS-CoV-2 相关莫旺综合征。
