口服葡萄糖试验中测量马匹脂代谢标志物的价值。

Value of measuring markers of lipid metabolism in horses during an oral glucose test.

机构信息

School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.

College of Veterinary Medicine, Purdue University, West-Lafayette, Indiana, USA.

出版信息

J Vet Intern Med. 2024 Nov-Dec;38(6):3309-3314. doi: 10.1111/jvim.17199. Epub 2024 Sep 18.

DOI:10.1111/jvim.17199

PMID:39291576

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11586554/

Abstract

BACKGROUND

Characterizing the lipid response to an oral glucose test (OGT) might improve our understanding of Equine Metabolic Syndrome.

HYPOTHESIS/OBJECTIVES: To describe the effects of an OGT on lipid metabolism and determine the value of measuring triglyceride and nonesterified fatty acid (NEFA) concentrations in hyperinsulinemic (HI) and insulin-resistant (IR) horses.

ANIMALS

Twenty horses including 7 HI-IR horses, 4 HI-non-IR horses, and 9 non-HI-non-IR horses (control).

METHODS

Cross-sectional design. Horses underwent an OGT, with blood samples collected at 0, 60, 90, and 120 minutes. Insulin, glucose, triglyceride, and NEFA concentrations were measured and compared over time and between groups, with P < .05 considered significant.

RESULTS

In all horses, the OGT had a significant effect on triglyceride concentrations (median [interquartile range]: .35 [.30-.50] mmol/L at 0 minute vs .25 [.21-.37] mmol/L at 120 minutes, P = .005) and on NEFA concentrations (.1 [.1-.2] mEq/L at 0 minute vs .05 [.05-.1] mEq/L at 120 minutes, P = .0009). However, horses with HI and IR had higher triglyceride areas under the curve (AUC, 79.46 ± 46.59 vs 33.32 ± 6.75 mmol/Lmin, P = .01) as well as NEFA AUC (9.1 ± 2.9 vs 6.0 ± 6.8 mEq/Lmin, P = .03) than control horses. No significant difference was detected between control and HI non-IR horses.

CONCLUSIONS AND CLINICAL IMPORTANCE

Determining triglyceride and NEFA concentrations might help assess tissue insulin resistance during an OGT.

摘要

背景

描述口服葡萄糖耐量试验（OGT）对脂质代谢的影响，有助于我们了解马属动物代谢综合征。

假说/目的：描述 OGT 对脂质代谢的影响，并确定在高胰岛素血症（HI）和胰岛素抵抗（IR）马中测量甘油三酯和非酯化脂肪酸（NEFA）浓度的价值。

动物

20 匹马，包括 7 匹 HI-IR 马、4 匹 HI-非 IR 马和 9 匹非 HI-非 IR 马（对照组）。

方法

横断面设计。所有马匹均接受 OGT，在 0、60、90 和 120 分钟时采集血样。测量胰岛素、血糖、甘油三酯和 NEFA 浓度，并在时间和组间进行比较，P <.05 为差异有统计学意义。

结果

所有马匹的 OGT 对甘油三酯浓度均有显著影响（中位数[四分位间距]：0 分钟时为 0.35 [0.30-0.50] mmol/L，120 分钟时为 0.25 [0.21-0.37] mmol/L，P =.005）和 NEFA 浓度（0 分钟时为 0.1 [0.1-0.2] mEq/L，120 分钟时为 0.05 [0.05-0.1] mEq/L，P =.0009）。然而，HI 和 IR 马的甘油三酯曲线下面积（AUC，79.46 ± 46.59 vs 33.32 ± 6.75 mmol/Lmin，P =.01）和 NEFA AUC（9.1 ± 2.9 vs 6.0 ± 6.8 mEq/Lmin，P =.03）均高于对照组。对照组和 HI 非 IR 组之间未检测到差异。