Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Neurology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Food Funct. 2024 Sep 30;15(19):10088-10098. doi: 10.1039/d4fo02796e.
Migraine is a complex neurovascular disorder characterized by recurrent headache attacks that are often accompanied by symptoms such as vomiting, nausea, and sensitivity to sound or light. Preventing migraine attacks is highly important. Recent research has indicated that alterations in gut microbiota may influence the underlying mechanisms of migraines. This study aimed to investigate the effects of inulin supplementation on migraine headache characteristics, quality of life (QOL), and mental health symptoms in women with migraines. In a randomized double-blind placebo-controlled trial, 80 women with migraines aged 20 to 50 years were randomly assigned to receive 10 g day of inulin or a placebo supplement for 12 weeks. Severity, frequency, and duration of migraine attacks, as well as depression, anxiety, stress, QOL, and headache impact test (HIT-6) scores, were examined at the start of the study and after 12 weeks of intervention. In this study, the primary outcome focused on the frequency of headache attacks, while secondary outcomes encompassed the duration and severity of headache attacks, QOL, and mental health. There was a significant reduction in severity (-1.95 -0.84, = 0.004), duration (-6.95 -2.05, = 0.023), frequency (-2.09 -0.37, < 0.001), and HIT-6 score (-10.30 -6.52, < 0.023) in the inulin group compared with the control. Inulin supplementation improved mental health symptoms, including depression (-4.47 -1.45, < 0.001), anxiety (-4.37 -0.70, < 0.001), and stress (-4.40 -1.50, < 0.001). However, no significant difference was observed between the two groups regarding changes in QOL score. This study provides evidence supporting the beneficial effects of inulin supplement on migraine symptoms and mental health status in women with migraines. Further studies are necessary to confirm these findings. Iranian Registry of Clinical Trials (https://www.irct.ir) (ID: IRCT20121216011763N58).
偏头痛是一种复杂的神经血管疾病，其特征是反复发作的头痛，常伴有呕吐、恶心和对声音或光线敏感等症状。预防偏头痛发作非常重要。最近的研究表明，肠道微生物群的改变可能会影响偏头痛的潜在机制。本研究旨在探讨菊粉补充剂对偏头痛女性偏头痛特征、生活质量（QOL）和心理健康症状的影响。在一项随机、双盲、安慰剂对照试验中，80 名年龄在 20 至 50 岁之间的偏头痛女性被随机分配接受 10 克/天的菊粉或安慰剂补充剂，干预时间为 12 周。在研究开始时和干预 12 周后，检查偏头痛发作的严重程度、频率和持续时间，以及抑郁、焦虑、压力、QOL 和头痛影响测试（HIT-6）评分。本研究的主要结局是头痛发作的频率，次要结局包括头痛发作的持续时间和严重程度、QOL 和心理健康。与对照组相比，菊粉组的严重程度（-1.95 -0.84， = 0.004）、持续时间（-6.95 -2.05， = 0.023）、频率（-2.09 -0.37， < 0.001）和 HIT-6 评分（-10.30 -6.52， < 0.023）均显著降低。菊粉补充剂改善了心理健康症状，包括抑郁（-4.47 -1.45， < 0.001）、焦虑（-4.37 -0.70， < 0.001）和压力（-4.40 -1.50， < 0.001）。然而，两组之间 QOL 评分的变化没有显著差异。本研究为菊粉补充剂对偏头痛女性偏头痛症状和心理健康状况的有益影响提供了证据。需要进一步的研究来证实这些发现。 伊朗临床试验注册中心（https://www.irct.ir）（ID：IRCT20121216011763N58）。
