1 Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Cephalalgia. 2019 Apr;39(5):648-654. doi: 10.1177/0333102418821661. Epub 2019 Jan 6.
The present study aimed to determine the effects of combined supplementation of Coenzyme Q10 with L-carnitine on mitochondrial metabolic disorders marker and migraine symptoms among migraine patients.
A total of 56 men and women, between 20-40 years of age with migraine headache, participated in this randomized, double-blind, placebo-controlled, parallel study. The subjects were randomly assigned to receive either 30 mg/day Coenzyme Q10 and 500 mg/day L-carnitine at the same time and/or placebo tablets for 8 weeks. The measurements were completed at the beginning and end of the study. The primary outcome was severity of headache attacks. The secondary outcomes included duration, frequency of headache attacks, the headache diary results (HDR), and serum levels of lactate.
A significant reduction was obtained in serum levels of lactate (-2.28 mg/dl, 95% CI: -3.65, -0.90; p = 0.002), severity (-3.03, 95% CI: -3.65, -2.40; p ≤ 0.001), duration (-7.67, 95% CI: -11.47, -3.90; p ≤ 0.001), frequency (-5.42, 95% CI: -7.31, -3.53; p ≤ 0.001) and HDR (-103.03, 95% CI: -145.76, -60.29; p ≤ 0.001) after 8 weeks.
This double-blind parallel study provides evidences supporting the beneficial effects of Coenzyme Q10 and L-carnitine supplements on serum levels of lactate and migraine symptoms.
IRCT20121216011763N21.
本研究旨在确定辅酶 Q10 与左旋肉碱联合补充对偏头痛患者线粒体代谢紊乱标志物和偏头痛症状的影响。
共有 56 名年龄在 20-40 岁之间的偏头痛患者参与了这项随机、双盲、安慰剂对照、平行研究。受试者被随机分为两组，分别同时服用 30mg/天辅酶 Q10 和 500mg/天左旋肉碱和安慰剂片剂，共 8 周。在研究开始和结束时完成测量。主要结果是头痛发作的严重程度。次要结果包括头痛发作的持续时间、频率、头痛日记结果（HDR）和血清乳酸水平。
血清乳酸水平显著降低（-2.28mg/dl，95%CI：-3.65，-0.90；p=0.002），严重程度（-3.03，95%CI：-3.65，-2.40；p≤0.001），持续时间（-7.67，95%CI：-11.47，-3.90；p≤0.001），频率（-5.42，95%CI：-7.31，-3.53；p≤0.001）和 HDR（-103.03，95%CI：-145.76，-60.29；p≤0.001）在 8 周后。
这项双盲平行研究提供了证据支持辅酶 Q10 和左旋肉碱补充剂对血清乳酸水平和偏头痛症状的有益影响。
IRCT20121216011763N21。
