Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Department of Diagnostics and Intervention, Radiation Physics and Biomedical Engineering, Umeå University, Umeå, Sweden.
Blood Press. 2024 Dec;33(1):2405161. doi: 10.1080/08037051.2024.2405161. Epub 2024 Sep 18.
Aortic stiffness, assessed as estimated aortic pulse wave velocity (aPWV), and carotid intima-media thickness (cIMT) are markers of vascular age, and carotid plaques are a marker of early atherosclerosis. In this cross-sectional study we aimed to investigate the association between aPWV, cIMT and plaques across different age groups and in women and men, in a middle-aged healthy population.
Participants in the 6.5-year follow-up of the VIPVIZA trial who were aged 47, 57 and 67 underwent an oscillometric measurement which estimates aPWV between 2020 and 2023. Carotid ultrasound examinations were also performed. Linear and ordinal regression models were used to investigate how aPWV associates with cIMT and with carotid plaques, for the overall study group and stratified for age groups and sex.
A total of 1046 subjects were included in the analyses. Linear associations between aPWV and cIMT (β = 0.018, 95% CI: 0.006-0.030, = 0.003), and between aPWV and plaques (OR: 1.19, 95% CI: 1.03-1.38, = 0.018), were seen in the 57-year-olds. In the 47-year-olds a significant association was seen between aPWV and plaques (OR: 2.98 95% CI: 1.44-6.14, = 0.003). No significant associations were seen in the 67-year-olds. For women, a significant association between aPWV and cIMT (β = 0.011, 95% CI: 0.004-0.017, = 0.002) was shown.
Estimated aPWV was positively associated with increasing cIMT and the presence of carotid plaques in younger middle-aged individuals, and with cIMT in women, suggesting that measurement of estimated aPWV may improve cardiovascular risk assessment in younger middle-aged individuals and women.Clinical Trial Registration date 8 May 2013: URL: www.clinicaltrials.gov. Unique identifier: NCT01849575.
主动脉僵硬度，通过估计的主动脉脉搏波速度（aPWV）来评估，以及颈动脉内膜中层厚度（cIMT），是血管年龄的标志物，颈动脉斑块是早期动脉粥样硬化的标志物。在这项横断面研究中，我们旨在研究不同年龄段的人群中，以及男性和女性中，aPWV、cIMT 和斑块之间的相关性，在中年健康人群中。
参加 VIPVIZA 试验 6.5 年随访的参与者年龄为 47、57 和 67 岁，在 2020 年至 2023 年期间接受了血压计测量，以估计 aPWV。还进行了颈动脉超声检查。线性和有序回归模型用于研究 aPWV 与 cIMT 和颈动脉斑块之间的关系，适用于整个研究组，并按年龄组和性别分层。
共有 1046 名受试者纳入分析。在 57 岁人群中，aPWV 与 cIMT 之间存在线性关联（β=0.018，95%CI：0.006-0.030，=0.003），aPWV 与斑块之间存在线性关联（OR：1.19，95%CI：1.03-1.38，=0.018）。在 47 岁人群中，aPWV 与斑块之间存在显著关联（OR：2.98，95%CI：1.44-6.14，=0.003）。在 67 岁人群中未观察到显著关联。对于女性，aPWV 与 cIMT 之间存在显著关联（β=0.011，95%CI：0.004-0.017，=0.002）。
估计的 aPWV 与年轻中年个体中 cIMT 的增加和颈动脉斑块的存在呈正相关，与女性的 cIMT 呈正相关，这表明测量估计的 aPWV 可能会改善年轻中年个体和女性的心血管风险评估。临床试验注册日期 2013 年 5 月 8 日：网址：www.clinicaltrials.gov。独特标识符：NCT01849575。
