College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, China.
Microbiol Spectr. 2024 Nov 5;12(11):e0061124. doi: 10.1128/spectrum.00611-24. Epub 2024 Sep 18.
This study explores the effects of disinfectant and antibiotic exposure on gut health, focusing on gut microbiota balance and gut immune function. Our analysis indicates that disinfectants increase the proportion of Gram-positive bacteria, particularly increasing levels, while antibiotics increase the proportion of Gram-negative bacteria, especially levels. These changes disrupt microbial harmony and affect the gut microbiome's functional capacity. Additionally, our research reveals that both disinfectants and antibiotics reduce colon length and cause mucosal damage. A significant finding is the downregulation of , a key immune system regulator in the gut, accompanied by changes in immune factor expression. This interaction between chemical exposure and immune system dysfunction increases susceptibility to inflammatory bowel disease and other gut conditions. Given the importance of disinfectants in disease prevention, this study advocates for a balanced approach to their use, aiming to protect public health while minimizing adverse effects on the gut microbiome and immune function.
Disinfectants are extensively employed across various sectors, such as the food sector. Disinfectants are widely used in various sectors, including the food processing industry, animal husbandry, households, and pharmaceuticals. Their extensive application risks environmental contamination, impacting water and soil quality. However, the effect of disinfectant exposure on the gut microbiome and the immune function of animals remains a significant, unresolved issue with profound public health implications. This highlights the need for increased scrutiny and more regulated use of disinfectants to mitigate unintended consequences on gut health and maintain immune system integrity.
本研究探讨了消毒剂和抗生素暴露对肠道健康的影响，重点关注肠道微生物群落平衡和肠道免疫功能。我们的分析表明，消毒剂会增加革兰氏阳性菌的比例，特别是增加 的水平，而抗生素会增加革兰氏阴性菌的比例，特别是 的水平。这些变化破坏了微生物的和谐，影响了肠道微生物组的功能能力。此外，我们的研究还表明，消毒剂和抗生素都会缩短结肠长度并导致黏膜损伤。一个重要的发现是 的下调，这是肠道中免疫系统的关键调节剂，伴随着免疫因子表达的变化。这种化学暴露与免疫系统功能障碍之间的相互作用增加了患炎症性肠病和其他肠道疾病的易感性。鉴于消毒剂在疾病预防中的重要性，本研究提倡平衡使用消毒剂的方法，旨在保护公众健康的同时，将对肠道微生物群和免疫功能的不利影响降到最低。
消毒剂在食品等多个领域得到广泛应用。消毒剂在食品加工业、畜牧业、家庭和制药等多个领域得到广泛应用。它们的广泛应用有导致环境污染的风险，影响水和土壤质量。然而，消毒剂暴露对动物肠道微生物群和免疫功能的影响仍然是一个重大的、未解决的问题，对公共健康有深远的影响。这突显了需要更严格的审查和更受监管的消毒剂使用，以减轻对肠道健康和免疫系统完整性的意外影响。
