Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Central Campus, Navrangpura, Ahmedabad 380009, Gujarat, India.
Nanoscale. 2024 Oct 10;16(39):18274-18294. doi: 10.1039/d4nr02795g.
Breast cancer is a significant global health issue. Tumor-associated macrophages (TAMs) are crucial in influencing the tumor microenvironment and the progression of the disease. TAMs exhibit remarkable plasticity in adopting distinct phenotypes ranging from pro-inflammatory and anti-tumorigenic (M1-like) to immunosuppressive and tumor-promoting (M2-like). This review elucidates the multifaceted roles of TAMs in driving breast tumor growth, angiogenesis, invasion, and metastatic dissemination. Significantly, it highlights the intricate crosstalk between TAMs and non-coding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, as a crucial regulatory mechanism modulating TAM polarization and functional dynamics that present potential therapeutic targets. Nanotechnology-based strategies are explored as a promising approach to reprogramming TAMs toward an anti-tumor phenotype. Various nanoparticle delivery systems have shown potential for modulating TAM polarization and inhibiting tumor-promoting effects. Notably, nanoparticles can deliver ncRNA therapeutics to TAMs, offering unique opportunities to modulate their polarization and activity.
乳腺癌是一个重大的全球健康问题。肿瘤相关巨噬细胞（TAMs）在影响肿瘤微环境和疾病进展方面起着至关重要的作用。TAMs 在表现出不同表型的能力上具有显著的可塑性，从促炎和抗肿瘤（M1 样）到免疫抑制和促进肿瘤（M2 样）。这篇综述阐明了 TAMs 在推动乳腺肿瘤生长、血管生成、侵袭和转移扩散中的多方面作用。值得注意的是，它强调了 TAMs 与非编码 RNA（ncRNA）之间的复杂相互作用，包括 microRNAs、长非编码 RNA 和环状 RNA，作为调节 TAM 极化和功能动态的关键调控机制，为治疗提供了潜在的靶点。基于纳米技术的策略被探索作为一种有前途的方法，用于将 TAMs 重新编程为抗肿瘤表型。各种纳米颗粒递送系统已显示出调节 TAM 极化和抑制促进肿瘤作用的潜力。值得注意的是，纳米颗粒可以将 ncRNA 治疗药物递送到 TAMs 中，为调节其极化和活性提供了独特的机会。
