Xu Shan, Yang Ning
Department of Otolaryngology, The First Hospital of China Medical University, Shenyang, 110001, China.
Mol Neurobiol. 2025 Jun;62(6):6913-6921. doi: 10.1007/s12035-024-04470-4. Epub 2024 Sep 18.
Hearing loss is one of the most common human diseases, seriously affecting everyday lives. Mitochondria, as the energy metabolism center in cells, are also involved in regulating active oxygen metabolism and mediating the occurrence of inflammation and apoptosis. Mitochondrial defects are closely related to hearing diseases. Studies have shown that mitochondrial DNA mutations are one of the causes of hereditary hearing loss. In addition, changes in mitochondrial homeostasis are directly related to noise-induced hearing loss and presbycusis. This review mainly summarizes and discusses the effects of mitochondrial dysfunction and mitophagy on hearing loss. Subsequently, we introduce the recent research progress of targeted mitochondria therapy in the hearing system.
听力损失是人类最常见的疾病之一，严重影响日常生活。线粒体作为细胞中的能量代谢中心，也参与调节活性氧代谢，并介导炎症和细胞凋亡的发生。线粒体缺陷与听力疾病密切相关。研究表明，线粒体DNA突变是遗传性听力损失的原因之一。此外，线粒体稳态的变化与噪声性听力损失和老年性耳聋直接相关。本综述主要总结和讨论线粒体功能障碍和线粒体自噬对听力损失的影响。随后，我们介绍了听力系统中靶向线粒体治疗的最新研究进展。
