芬氟咪唑对家兔离体组织环氧化酶的选择性抑制作用。
Selective inhibition by fenflumizole tissue cyclooxygenase in rabbits ex vivo.
作者信息
Basista M, Grodzińska L, Gryglewski R J
出版信息
Pol J Pharmacol Pharm. 1985 Jan-Feb;37(1):41-6.
A new non-steroidal anti-inflammatory drug fenflumizole when administered orally to rabbits at therapeutic doses of 10 and 30 mg/kg affects neither PGI2 generation by arterial slices nor PGE2 generation by gastric mucosa, respectively. Fenflumizole at doses of 10 and 30 mg/kg per os inhibits platelet aggregability and generation of TXA2 by platelets. It is suggested that this selective action of fenflumizole on tissue cyclooxygenase ex vivo may justify with fenflumizole in anti-thrombotic therapy.
一种新型非甾体抗炎药芬氟米唑，以10毫克/千克和30毫克/千克的治疗剂量口服给予兔子时，分别对动脉切片生成前列环素（PGI2）和胃黏膜生成前列腺素E2（PGE2）均无影响。芬氟米唑以10毫克/千克和30毫克/千克的剂量口服可抑制血小板聚集性以及血小板生成血栓素A2（TXA2）。提示芬氟米唑在体外对组织环氧化酶的这种选择性作用可能为其在抗血栓治疗中的应用提供依据。
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