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髋部骨折置换术后10年生存率的患者相关因素:加拿大安大略省的一项基于人群的研究

Patient Factors Associated with 10-Year Survival After Arthroplasty for Hip Fracture: A Population-Based Study in Ontario, Canada.

作者信息

Tohidi Mina, Grammatopoulos George, Mann Stephen M, Pysklywec Alexandra, Groome Patti A

机构信息

Department of Surgery, Queen's University, Kingston, Ontario, Canada.

The Ottawa Hospital, Ottawa, Ontario, Canada.

出版信息

J Bone Joint Surg Am. 2024 Nov 20;106(22):2073-2084. doi: 10.2106/JBJS.24.00379. Epub 2024 Sep 18.

Abstract

BACKGROUND

The aim of this study was to describe long-term (10-year) patient survival after arthroplasty for hip fracture and to determine what patient factors are associated with that outcome.

METHODS

We performed a retrospective cohort analysis of patients ≥60 years old who underwent either hemiarthroplasty or total hip arthroplasty for femoral neck fracture between 2002 and 2009. We used routinely collected, validated health-care databases linked through ICES (formerly known as the Institute for Clinical Evaluative Sciences). We estimated the association between baseline variables and survival 10 years post-fracture using Poisson regression. Restricted cubic spline functions modeled the probability of 10-year survival by age and tested whether there was an inflection point after which the probability of 10-year survival decreased more rapidly. We estimated 10-year survival probabilities for different patient groups.

RESULTS

There were 19,659 patients in the final cohort. Eighteen percent (3,564) of the patients were alive at 10 years postoperatively. Factors associated with a higher likelihood of 10-year survival included younger age, female sex (risk ratio [RR] = 1.56, 95% confidence interval [CI] = 1.46 to 1.68), lower American Society of Anesthesiologists (ASA) class (ASA I or II versus IV or V: RR = 1.96, 95% CI = 1.76 to 2.19), independent living status (RR = 2.68, 95% CI = 2.23 to 3.22), and fewer specific comorbidities. A threshold age of 73 years was the inflection point after which the probability of 10-year survival decreased more rapidly in females. Estimated 10-year survival probabilities ranged from 79.0% (95% CI = 75.5% to 82.5%) to 0.8% (95% CI = 0.6% to 1.0%).

CONCLUSIONS

Approximately 1 in 6 patients live at least 10 years following a hip fracture. This study identifies baseline characteristics that predict survival greater than 10 years, including an age of <75 years, an ASA class of I or II, and independent living status prior to the hip fracture. Results can inform discussions around treatment choices, anticipated outcomes, and the natural history of hip fractures.

LEVEL OF EVIDENCE

Prognostic Level III . See Instructions for Authors for a complete description of levels of evidence.

摘要

背景

本研究的目的是描述髋部骨折关节置换术后的长期(10年)患者生存率,并确定哪些患者因素与该结果相关。

方法

我们对2002年至2009年间因股骨颈骨折接受半髋关节置换术或全髋关节置换术的60岁及以上患者进行了回顾性队列分析。我们使用通过ICES(前身为临床评估科学研究所)链接的常规收集的、经过验证的医疗保健数据库。我们使用泊松回归估计基线变量与骨折后10年生存率之间的关联。受限立方样条函数通过年龄对10年生存概率进行建模,并测试是否存在一个拐点,在该拐点之后10年生存概率下降得更快。我们估计了不同患者组的10年生存概率。

结果

最终队列中有19659名患者。18%(3564名)的患者术后10年仍存活。与10年生存率较高可能性相关的因素包括年龄较小、女性(风险比[RR]=1.56,95%置信区间[CI]=1.46至1.68)、较低的美国麻醉医师协会(ASA)分级(ASA I或II级与IV或V级相比:RR=1.96,95%CI=1.76至2.19)、独立生活状态(RR=2.68,95%CI=2.23至3.22)以及较少的特定合并症。73岁的阈值年龄是拐点,在该年龄之后,女性10年生存概率下降得更快。估计的10年生存概率范围从79.0%(95%CI=75.5%至82.5%)到0.8%(95%CI=0.6%至1.0%)。

结论

大约六分之一的患者在髋部骨折后至少存活10年。本研究确定了预测生存超过10年的基线特征,包括年龄<75岁、ASA分级为I或II级以及髋部骨折前的独立生活状态。研究结果可为围绕治疗选择、预期结果和髋部骨折自然史的讨论提供参考。

证据水平

预后III级。有关证据水平的完整描述,请参阅作者指南。

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