Rucăreanu C, Popescu D, Frangopol P T
Physiologie. 1985 Apr-Jun;22(2):109-15.
A study on the influence of procaine on both active and passive transport properties of isolated frog skin, at temperatures ranging between 15 and 25 degrees C and at increasing concentrations up to 2%, was carried out. The active transport of sodium as expressed by the short-circuit current, is inhibited when procaine is added to the solution bathing the inside of the skin, the inhibition being steeper at higher concentrations. No apparent effect of procaine with temperature was noticed. The Na and K ionic flows were measured by flam-photometric dosimetry allowing a 10(-5) Kg. m-2 s-1 sensitivity. The diffusional potassium flow through frog skin was stimulated, while the diffusional sodium flow was inhibited by procaine. The stimulation of potassium diffusion was more evident at lower procaine concentrations, whereas the inhibition of sodium diffusion was more evident at higher procaine concentrations.
在15至25摄氏度的温度范围内，对高达2%的递增浓度的普鲁卡因对离体蛙皮主动和被动转运特性的影响进行了研究。当将普鲁卡因添加到皮肤内侧的浴液中时，以短路电流表示的钠的主动转运受到抑制，浓度越高抑制作用越明显。未观察到普鲁卡因对温度有明显影响。通过火焰光度剂量法测量钠和钾离子流，灵敏度为10(-5)千克·米-2·秒-1。普鲁卡因刺激了蛙皮中钾的扩散流，而抑制了钠的扩散流。较低浓度的普鲁卡因对钾扩散的刺激作用更明显，而较高浓度的普鲁卡因对钠扩散的抑制作用更明显。
