College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China.
Nansha-South China Agricultural University Fishery Research Institute, Guangzhou 511464, China.
J Agric Food Chem. 2024 Oct 2;72(39):21610-21623. doi: 10.1021/acs.jafc.4c05464. Epub 2024 Sep 18.
Fucoxanthin, a dietary carotenoid, is predominantly found in edible brown algae and is commonly consumed worldwide. Fucoxanthin has been shown to possess beneficial health activities such as antidiabetic, anti-inflammatory, antimutagenic, and antiobesity; however, the effects of fucoxanthin on VEGF-mediated angiogenesis and its possible binding with VEGF are unknown. Here, different lines of evidence supported the suppressive roles of fucoxanthin in VEGF-mediated angiogenesis. In human umbilical vein endothelial cells, fucoxanthin remarkedly suppressed VEGF-mediated cell proliferative, migration, and invasive abilities, as well as tube formation, without cytotoxicity. In addition, fucoxanthin inhibited the subintestinal vessel formation of zebrafish . In signaling cascades, fucoxanthin was proposed to interact with VEGF, thus attenuating VEGF's functions in activating the VEGF receptor and its related downstream signaling, i.e., phosphorylations of MEK and Erk. Fucoxanthin also significantly blocked VEGF-triggered ROS formation. Furthermore, the outcomes of applying fucoxanthin in cancer cells were identified, which included (i) inhibiting VEGF-mediated cell proliferation and migration and (ii) inhibiting NF-κB translocation limiting MMP2 expression. These lines of investigations supported the antiangiogenic roles of fucoxanthin, as well as reviewing its signaling mechanisms, in blocking the VEGF-triggered responses. The results would benefit the potential development of fucoxanthin for the prevention and treatment of angiogenesis-related diseases.
岩藻黄质是一种饮食类胡萝卜素，主要存在于可食用的褐藻中，在世界范围内广泛食用。岩藻黄质已被证明具有有益的健康活性，如抗糖尿病、抗炎、抗突变和抗肥胖；然而，岩藻黄质对 VEGF 介导的血管生成及其与 VEGF 可能的结合的影响尚不清楚。在这里，不同的证据支持岩藻黄质在 VEGF 介导的血管生成中的抑制作用。在人脐静脉内皮细胞中，岩藻黄质显著抑制 VEGF 介导的细胞增殖、迁移和侵袭能力，以及管形成，而没有细胞毒性。此外，岩藻黄质抑制了斑马鱼的亚肠道血管形成。在信号级联中，岩藻黄质被提出与 VEGF 相互作用，从而减弱 VEGF 激活 VEGF 受体及其相关下游信号的功能，即 MEK 和 Erk 的磷酸化。岩藻黄质还显著阻断了 VEGF 触发的 ROS 形成。此外，还确定了在癌细胞中应用岩藻黄质的结果，包括（i）抑制 VEGF 介导的细胞增殖和迁移，以及（ii）抑制 NF-κB 易位限制 MMP2 表达。这些研究结果支持了岩藻黄质的抗血管生成作用，并回顾了其阻断 VEGF 触发反应的信号机制。这些结果将有利于岩藻黄质在预防和治疗血管生成相关疾病方面的潜在发展。
