Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark.
Eur J Endocrinol. 2024 Sep 30;191(4):381-388. doi: 10.1093/ejendo/lvae115.
Age at pubertal onset has decreased over the recent decades. Early maturing girls have longer puberty duration, and higher peak height velocity (PHV) than late maturing girls. To what extent this is generated by increased insulin-like growth factor-I (IGF-I), fat mass, or fasting insulin levels is currently unknown.
DESIGN, SETTING, PARTICIPANTS: A population-based study-part of the COPENHAGEN puberty study-longitudinal part. Eighty-one girls evaluated biannually for a median of 10 (2-15) visits for a total of 815 evaluations.
Pubertal staging, anthropometric measures, PHV, skin fold thickness (SFT), and IGF-I and fasting insulin levels were measured.
Early maturing girls achieved similar final height compared to late maturing girls (166.1 vs 167.1 cm, P = .36). Early pubertal onset was associated with significantly greater PHV (8.7 vs 7.4 cm/year, P < .001) and a longer puberty duration (age at onset of breast development to age at PHV [1.8 vs 1.1 years, P < .001]) compared with late maturation. After correcting for age at pubertal onset, neither body mass index, SFT, nor IGF-I levels differed between early vs late maturing girls. By contrast, fasting insulin levels were significantly higher in early compared with late maturing girls 1.5, 2.0, and 3.0 years after pubertal onset (all P = .039).
Growth velocity was higher and more prolonged in early compared with late maturing girls and associated with higher insulin levels. Thus, the higher insulin levels may compensate for the shorter total growth period by intensifying the pubertal growth period.
NCT01411527.
近年来，青春期开始的年龄有所提前。性早熟的女孩青春期持续时间较长，峰值身高速度（PHV）较高。目前尚不清楚这在多大程度上是由胰岛素样生长因子-I（IGF-I）、脂肪量或空腹胰岛素水平的增加引起的。
设计、地点、参与者：一项基于人群的研究-哥本哈根青春期研究的一部分-纵向部分。81 名女孩每两年评估一次，中位数为 10（2-15）次就诊，总共进行了 815 次评估。
进行青春期分期、人体测量测量、PHV、皮褶厚度（SFT）以及 IGF-I 和空腹胰岛素水平的测量。
性早熟的女孩与晚熟的女孩达到相似的最终身高（166.1 厘米对 167.1 厘米，P =.36）。青春期早期开始与 PHV 显著更高（8.7 厘米/年对 7.4 厘米/年，P <.001）和青春期持续时间更长（从乳房发育开始到 PHV 的年龄[1.8 年对 1.1 年，P <.001]）相关，与晚熟相比。在纠正青春期开始年龄后，早期与晚期成熟的女孩的体重指数、SFT 或 IGF-I 水平没有差异。相比之下，空腹胰岛素水平在早期成熟的女孩中明显高于晚期成熟的女孩，分别为青春期开始后 1.5、2.0 和 3.0 年（均 P =.039）。
与晚熟的女孩相比，早期成熟的女孩生长速度更高且持续时间更长，与更高的胰岛素水平相关。因此，较高的胰岛素水平可能通过加强青春期生长阶段来弥补总生长周期较短。
NCT01411527。
