Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society. Karolinska Institutet, Stockholm, Sweden.
Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden; Centre for Epidemiology and Community Health, Stockholm Region, Sweden.
J Psychiatr Res. 2024 Nov;179:156-162. doi: 10.1016/j.jpsychires.2024.09.010. Epub 2024 Sep 10.
Exposure to parental substance use problems has been associated with offsprings poor health and adverse social outcomes. In this study, we examined the association between exposure to parental substance use disorder (SUD) during childhood, and adolescence and offspring psychiatric conditions in young adulthood.
This was a register-based cohort study comprising 562,095 males and 531,130 females born between 1981 and 1990 in Sweden. Parental SUD was captured between the offspring's birth and eighteenth birthday. Cox regression models were used to estimate the Hazard Ratio (HR) of psychiatric conditions from age 18 years to a maximum age of 35 years, from January 1, 1999 to December 31, 2016.
About 4% of the study population was exposed to parental SUD during childhood and adolescence. The HR of psychiatric diagnosis was higher in males (1.80, 95% CI = 1.77-1.85) and females (1.56, 95% CI = 1.51-1.60) who were exposed to parental SUD, compared to those who were not; after adjusting for year of birth, domicile, origin, relative poverty, and other parental psychiatric diagnoses. The risks of psychiatric conditions were higher among males and females exposed to parental SUD during childhood compared to during adolescence.
Exposure to parental SUD during childhood and adolescence was associated with an increased risk of psychiatric conditions in early adulthood for both males and females. Neither origin, poverty, municipality, or other parental psychiatric diagnoses fully explained the association. These risks seemed to be somewhat higher among males, and among those exposed during childhood when compared to during adolescence.
父母物质使用问题的暴露与后代的健康状况不佳和不良的社会后果有关。在这项研究中，我们研究了儿童期和青春期父母物质使用障碍（SUD）暴露与成年早期后代精神疾病之间的关系。
这是一项基于登记的队列研究，包括 1981 年至 1990 年期间在瑞典出生的 562095 名男性和 531130 名女性。父母 SUD 是在后代出生至 18 岁生日之间捕获的。使用 Cox 回归模型来估计从 18 岁到 35 岁的最大年龄的精神疾病的风险比（HR），从 1999 年 1 月 1 日至 2016 年 12 月 31 日。
研究人群中约有 4%的人在儿童期和青春期暴露于父母的 SUD。与未暴露于父母 SUD 的人相比，暴露于父母 SUD 的男性（1.80，95%CI=1.77-1.85）和女性（1.56，95%CI=1.51-1.60）发生精神诊断的 HR 更高；在调整了出生年份、住所、出身、相对贫困和其他父母精神诊断后。与暴露于青春期 SUD 相比，儿童期暴露于父母 SUD 的男性和女性患精神疾病的风险更高。
儿童期和青春期暴露于父母 SUD 与成年早期男性和女性精神疾病的风险增加有关。出身、贫困、市、或其他父母精神诊断并不能完全解释这种关联。与女性相比，男性和那些在儿童期而不是在青春期暴露于 SUD 的人，这种风险似乎略高。
