Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
J Affect Disord. 2025 Jan 1;368:564-572. doi: 10.1016/j.jad.2024.09.094. Epub 2024 Sep 16.
Obesity is a major concern in patients with bipolar disorder (BD) and problematic eating behaviors have been suggested to mediate their relationship. The association between problematic eating behaviors and obesity has been studied but limited data have explored the role of BD. We investigated problematic eating behaviors among patients with BD compared with candidates for bariatric surgery (BS), with or without BD, and explored the possible correlations between mood spectrum, impulsivity, body mass index (BMI).
50 euthymic patients with BD and 200 subjects eligible for BS, 48 with BD (BS + BD) and 152 without BD (BS-BD), were recruited at the Psychiatric Clinic of University of Pisa. Assessments included: Structured Clinical Interview (SCID-5), Emotional Eating Scale (EES), Yale Food Addiction Scale (YFAS), Eating Disorder Inventory (EDI-2), Eating Disorder Questionnaire (EDE-Q), Night Eating Scale (NES), Grazing Questionnaire (GQ), Mood Spectrum Self-Report (MOOD-SR), Barratt Impulsivity Scale (BIS).
BS + BD reported significantly higher EDI-2 and EDE-Q scores than the other groups. BD and BS + BD showed significantly higher BIS-11 scores than BS-BD. Among BS, EES and YFAS were associated with mood spectrum symptoms.
Small BD sample size, BS may have underreported psychiatric symptoms to get approved for surgery, the interview didn't inquire about BS receiving GLP-1 agonists therapy.
Results showed a high prevalence of problematic eating behaviors among patients with BD and severely obese. Problematic eating behaviors may aggravate BD symptoms. Mood spectrum symptoms in obese subjects need to be carefully researched in as relate to severity and post-surgical course of BS.
肥胖是双相情感障碍（BD）患者的一个主要关注点，有研究表明，有问题的进食行为可能是导致这种情况的原因。虽然已经研究了有问题的进食行为与肥胖之间的关系，但目前的数据仅限于探讨 BD 与肥胖之间的关系。我们研究了与肥胖相关的有问题的进食行为在 BD 患者中的表现，将其与接受减重手术（BS）的患者进行了比较，这些患者有的患有 BD，有的没有，同时还探讨了情绪谱、冲动性和体重指数（BMI）之间的可能相关性。
在比萨大学精神病诊所共招募了 50 名病情稳定的 BD 患者和 200 名符合 BS 条件的受试者，其中 48 名患有 BD（BS+BD），152 名没有 BD（BS-BD）。评估包括：SCID-5 定式访谈、情绪进食量表（EES）、耶鲁食物成瘾量表（YFAS）、饮食障碍问卷（EDI-2）、饮食障碍检查问卷（EDE-Q）、夜间进食量表（NES）、放牧问卷（GQ）、情绪谱自评量表（MOOD-SR）、巴瑞特冲动量表（BIS）。
BS+BD 组的 EDI-2 和 EDE-Q 评分显著高于其他组。BD 和 BS+BD 组的 BIS-11 评分显著高于 BS-BD 组。在 BS 组中，EES 和 YFAS 与情绪谱症状相关。
BD 样本量小，BS 可能为获得手术批准而未报告精神科症状，访谈未询问 BS 是否接受 GLP-1 激动剂治疗。
结果表明，BD 患者和严重肥胖患者中有很高的有问题的进食行为发生率。有问题的进食行为可能会加重 BD 症状。肥胖患者的情绪谱症状需要在与 BS 的严重程度和术后过程相关的方面进行深入研究。
