Pieragalli D, Forconi S, Guerrini M, Acciavatti A, Galigani C, Del Bigo C, Di Perri T
Ric Clin Lab. 1985;15 Suppl 1:79-86.
The authors show a new method to study erythrocyte aggregation; the results of in vitro study, obtained by modification of several parameters (hematocrit, immunoglobulins, fibrinogen concentrations), are exposed. The authors did not find in vivo correlations between MAE and hemorheological parameters in different diseases; they found low MAE values only in myelomatous subjects. Adding erythrocytes from healthy donors to myelomatous plasma and vice versa, they found low MAE values only in samples containing erythrocytes and plasma from myeloma. These results suggest that many factors, not only erythrocyte aggregability, contribute to determine MAE (Mean Aggregation Entity).
作者展示了一种研究红细胞聚集的新方法;文中公布了通过改变几个参数(血细胞比容、免疫球蛋白、纤维蛋白原浓度)获得的体外研究结果。作者未发现不同疾病中平均聚集指数(MAE)与血液流变学参数之间的体内相关性;仅在骨髓瘤患者中发现较低的MAE值。将健康供体的红细胞添加到骨髓瘤患者的血浆中,反之亦然,他们发现只有在含有骨髓瘤患者红细胞和血浆的样本中MAE值较低。这些结果表明,许多因素,不仅是红细胞聚集性,都有助于确定平均聚集指数(MAE)。