Kabi Fredrick, Contreras Marinela, Semakula Jimmy, Sánchez-Sánchez Marta, Muñoz-Hernández Clara, Mugerwa Swidiq, Kasaija Paul, Kirunda Halid, de la Fuente Gabriela, Fernández-Melgar Rubén, Rafael Marta, Fernández de Mera Isabel G, Matovu Moses, Kyakuwa Ivan, Dhikusooka Moses, Nsereko Godfrey, Boma Paul, Bugeza James, Moses Mwesigwa, Namukasa Agnes, Obonyo Philip, Ssekabunga Nicholas, Adyero Okeny E, Rutaisire Justus, Gortazar Christian, de la Fuente José
National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala, Uganda.
SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM), Ciudad Real, Spain.
NPJ Vaccines. 2024 Sep 18;9(1):174. doi: 10.1038/s41541-024-00966-1.
Vaccines are the most effective and sustainable intervention to control ticks and tick-borne diseases (TBD). Using a personalized vaccine design based on regional tick genotypes, a Rhipicephalus appendiculatus Subolesin protective antigen was used in a field trial evaluating tick vaccine efficacy, effectiveness, and safety in cattle infested with multiple tick species in different Ugandan agro-ecological zones. Vaccination with SUB was safe with a protective capacity against anemia and infection, and reduced the number of infested cattle, tick fitness (feeding and reproduction) with vaccine effectiveness against multiple tick species between 93.2% at 167-196 days post-vaccination (dpv) and 61.4% at 251-327 dpv. Total integrated vaccine efficacy/effectiveness was estimated as 98.8%. The Subolesin-based vaccine is protective against multiple cattle tick infestations under field conditions in Uganda. These results support registration and commercialization of the vaccine to reduce tick populations and associated risks for human and animal TBD and chemical acaracides in Uganda.
疫苗是控制蜱虫及蜱传疾病（TBD）最有效且可持续的干预措施。基于区域蜱虫基因型进行个性化疫苗设计，在乌干达不同农业生态区对感染多种蜱虫的牛群开展的一项田间试验中，使用了血红扇头蜱亚油酸异构酶保护性抗原评估蜱虫疫苗的效力、效果和安全性。接种SUB疫苗是安全的，具有预防贫血和感染的保护能力，减少了受蜱虫侵袭的牛的数量，降低了蜱虫的适应性（取食和繁殖），对多种蜱虫的疫苗效力在接种后167 - 196天为93.2%，在接种后251 - 327天为61.4%。总体综合疫苗效力/效果估计为98.8%。在乌干达的田间条件下，基于亚油酸异构酶的疫苗对多种牛蜱侵袭具有保护作用。这些结果支持该疫苗在乌干达注册并商业化，以减少蜱虫数量以及与人类和动物蜱传疾病及化学杀螨剂相关的风险。
